Evidence map›Paper›PMID 31993046›Full record

ArticleFrontiers in immunology2019

Pyridinecarboxylic Acid Derivative Stimulates Pro-Angiogenic Mediators by PI3K/AKT/mTOR and Inhibits Reactive Nitrogen and Oxygen Species and NF-κB Activation Through a PPARγ-Dependent Pathway in

Federico Nicolás Penas, Davide Carta, Ágata Carolina Cevey, María Jimena Rada, Azul Victoria Pieralisi, María Grazia Ferlin, María Elena Sales, Gerardo A Mirkin, Nora Beatriz Goren

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. mTOR Signaling in Macrophages: All Depends on the Context.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Review
  5. Modulation of autophagy as a therapeutic strategy forFrontiers in cellular and infection microbiology · 2022
    Review
  6. Review
  7. Article
  8. [Balectin-3 affects the stability of vulnerable coronary atherosclerosis plaques by targeted modulation of lncARSR].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021
    Article
  9. Review
  10. Article
  11. Article
  12. Annals of translational medicine · 2020
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Federico Nicolás PenasDepartamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Davide CartaDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
Ágata Carolina CeveyDepartamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
María Jimena RadaDepartamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Azul Victoria PieralisiDepartamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
María Grazia FerlinDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
María Elena SalesCentro de Estudios Farmacológicos y Botánicos (CEFyBO), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina.
Gerardo A MirkinDepartamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Nora Beatriz GorenDepartamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Instituto de Investigaciones Biomédicas en Retrovirus y Sida · ARConsejo Nacional de Investigaciones Científicas y Técnicas · ARUniversity of Buenos Aires · ARUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease is caused by

Indexed as

Angiogenesis Inducing AgentsAnimalsAnti-Inflammatory AgentsAntiprotozoal AgentsChagas DiseaseHumansHydrogen PeroxideIsonicotinic AcidsMacrophagesMaleMiceMice, Inbred BALB CNitric Oxide Synthase Type IIIPhosphatidylinositol 3-KinasesPPAR gammaProto-Oncogene Proteins c-akt3-hydroxy-4-pyridinecarboxylic acidAngiogenesis Inducing AgentsAnti-Inflammatory AgentsAntiprotozoal AgentsHydrogen PeroxideIsonicotinic AcidsNitric Oxide Synthase Type IIIPhosphatidylinositol 3-KinasesPPAR gammaProto-Oncogene Proteins c-aktReactive Nitrogen SpeciesReactive Oxygen SpeciesVascular Endothelial Growth Factor Amacrophagesnew PPARγ ligandNF-κB pathwayPI3K/AKT/mTORTrypanosoma cruzi

Identifiers

PMID31993046
PMCPMC6964702
OpenAlexW2993964247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.