ReviewFrontiers in physiology2019
Locomotor Muscles in COPD: The Rationale for Rehabilitative Exercise Training.
Review in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Locomotor muscle dysfunction and rehabilitative exercise training in fibrotic interstitial lung disease: Where are we at and where could we go?Experimental physiology · 2026Review
- Exercise and Epigenetic Regulation in COPD: Current Evidence and Potential Mechanistic Pathways.International journal of molecular sciences · 2025Review
- On the effectiveness of rehabilitative exercise training in COPD: why does contractile muscle fatigue matter?ERJ open research · 2025Article
- Does quadriceps contractile fatigue influence rehabilitation outcomes in COPD-chronic respiratory failure patients?ERJ open research · 2025Article
- Differential patterns of the relationship between exercise dose and mortality risk across severities of airflow limitation: a prospective cohort study with a 5-year follow-up period.Journal of rehabilitation medicine · 2025Article
- Test-retest reliability of cardiopulmonary exercise test-derived metrics in individuals with COPD versus healthy controls.Clinical physiology and functional imaging · 2025Article
- ERS International Congress 2023: highlights from the Respiratory Clinical Care and Physiology Assembly.ERJ open research · 2024Article
- Comparison of physical activity levels in people with chronic obstructive pulmonary disease and healthy subjects residing in hypobaric hypoxia environments.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2024Article
- Review
- Meta-analysis of the impact of physical activity on the recovery of physical function in COVID-19 patients.Heliyon · 2023Review
- The relationship between perceived and performance fatigability in severe fibrotic interstitial lung disease: a prospective, cross-sectional study.ERJ open research · 2023Article
- Breathing Control Exercises Delivered in a Group Setting for Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2023Article
- Improved clinical outcomes in response to a 12-week blended digital and community-based long-COVID-19 rehabilitation programme.Frontiers in medicine · 2023Article
- Role of nutrition in patients with coexisting chronic obstructive pulmonary disease and sarcopenia.Frontiers in nutrition · 2023Review
- Utility of Cardiopulmonary Exercise Testing in Chronic Obstructive Pulmonary Disease: A Review.International journal of chronic obstructive pulmonary disease · 2023Review
- Different Responses to Pulmonary Rehabilitation in COPD Patients with Different Work Efficiencies.International journal of chronic obstructive pulmonary disease · 2022Article
- The effect of a pressure ventilatory support on quadriceps endurance is maintained after exercise training in severe COPD patients. A longitudinal randomized, cross over study.Frontiers in physiology · 2022Article
- Update on the Etiology, Assessment, and Management of COPD Cachexia: Considerations for the Clinician.International journal of chronic obstructive pulmonary disease · 2022Review
- Role of progression of training volume on intramuscular adaptations in patients with chronic obstructive pulmonary disease.Frontiers in physiology · 2022Article
- Impact of extrapulmonary comorbidities on physical activity in chronic obstructive pulmonary disease in Japan: A cross-sectional study.PloS one · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise training as part of pulmonary rehabilitation is arguably the most effective intervention to improve tolerance to physical exertion in patients with chronic obstructive pulmonary disease (COPD). Owing to the fact that exercise training has modest effects on exertional ventilation, operating lung volumes and respiratory muscle performance, improving locomotor muscle structure and function are key targets for pulmonary rehabilitation in COPD. In the current concise review, we initially discuss whether patients' muscles are exposed to deleterious factors. After presenting corroboratory evidence on this regard (e.g., oxidative stress, inflammation, hypoxemia, inactivity, and medications), we outline their effects on muscle macro- and micro-structure and related functional properties. We then finalize by addressing the potential beneficial consequences of different training strategies on these muscle-centered outcomes. This review provides, therefore, an up-to-date outline of the rationale for rehabilitative exercise training approaches focusing on the locomotor muscles in this patient population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.