ArticleFrontiers in systems neuroscience2019
Cross-Frequency Coupling in Descending Motor Pathways: Theory and Simulation.
Article in Frontiers in systems neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Neuroengineering approaches assessing structural and functional changes of motor descending pathways in stroke.Progress in biomedical engineering (Bristol, England) · 2025Review
- Contralesional recruitment and localization of EEG signal complexity in stroke: a recurrence quantification analysis of hierarchical motor tasks.Journal of neural engineering · 2025Article
- Cross-frequency cortex-muscle interactions are abnormal in young people with dystonia.Brain communications · 2024Article
- Task-dependent Alteration in Delta Band Corticomuscular Coherence during Standing in Chronic Stroke Survivors.medRxiv : the preprint server for health sciences · 2023Article
- Cross-frequency and iso-frequency estimation of functional corticomuscular coupling after stroke.Cognitive neurodynamics · 2021Article
- Nonlinear System Identification of Neural Systems from Neurophysiological Signals.Neuroscience · 2021Review
- Slowly activating outward membrane currents generate input-output sub-harmonic cross frequency coupling in neurons.Journal of theoretical biology · 2021Article
- Assessing the Usage of Indirect Motor Pathways Following a Hemiparetic Stroke.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2021Article
- Assessing Neural Connectivity and Associated Time Delays of Muscle Responses to Continuous Position Perturbations.Annals of biomedical engineering · 2021Article
- Neuromechanical Biomarkers for Robotic Neurorehabilitation.Frontiers in neurorobotics · 2021Review
- From Motor-Output to Connectivity: An In-Depth Study ofFrontiers in insect science · 2021Article
- Quantifying the Nonlinear Interaction in the Nervous System Based on Phase-Locked Amplitude Relationship.IEEE transactions on bio-medical engineering · 2020Article
- Quantifying Altered Neural Connectivity of the Stretch Reflex in Chronic Hemiparetic Stroke.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2020Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Coupling of neural oscillations is essential for the transmission of cortical motor commands to motoneuron pools through direct and indirect descending motor pathways. Most studies focus on iso-frequency coupling between brain and muscle activities, i.e., cortico-muscular coherence, which is thought to reflect motor command transmission in the mono-synaptic corticospinal pathway. Compared to this direct pathway, indirect corticobulbospinal motor pathways involve multiple intermediate synaptic connections via spinal interneurons. Neuronal processing of synaptic inputs can lead to modulation of inter-spike intervals which produces cross-frequency coupling. This theoretical study aims to evaluate the effect of the number of synaptic layers in descending pathways on the expression of cross-frequency coupling between supraspinal input and the cumulative output of the motoneuron pool using a computer simulation. We simulated descending pathways as various layers of interneurons with a terminal motoneuron pool using Hogdkin-Huxley styled neuron models. Both cross- and iso-frequency coupling between the supraspinal input and the motorneuron pool output were computed using a novel generalized coherence measure, i.e., n:m coherence. We found that the iso-frequency coupling is only dominant in the mono-synaptic corticospinal tract, while the cross-frequency coupling is dominant in multi-synaptic indirect motor pathways. Furthermore, simulations incorporating both mono-synaptic direct and multi-synaptic indirect descending pathways showed that increased reliance on a multi-synaptic indirect pathway over a mono-synaptic direct pathway enhances the dominance of cross-frequency coupling between the supraspinal input and the motorneuron pool output. These results provide the theoretical basis for future human subject study quantitatively assessing motor command transmission in indirect vs. direct pathways and its changes after neurological disorders such as unilateral brain injury.
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