Evidence map›Paper›PMID 31992762›Full record

Trial reportScientific reports2020

Rethinking Measures of Functional Connectivity via Feature Extraction.

Rosaleena Mohanty, William A Sethares, Veena A Nair, Vivek Prabhakaran

Abstract readClinical Trial
In one paragraph

Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed.

  1. Article
  2. Review
  3. Temporal stability of functional network configurations and its relationship to cognition and psychopathology in early psychoses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Connectivity Regression.Biostatistics (Oxford, England) · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rosaleena MohantyDepartment of Radiology, University of Wisconsin-Madison, Madison, WI, USA. rosaleena.mohanty@ki.se.
William A SetharesElectrical Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Veena A NairDepartment of Radiology, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-5666-3239
Vivek PrabhakaranDepartment of Radiology, University of Wisconsin-Madison, Madison, WI, USA.

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
GENERAL PURPOSE BRAIN-COMPUTER INTERFACE(BCI)SYSTEMR01EB000856 · NIBIB · WADSWORTH CENTER · PI SCHALK, GERWIN, WOLPAW, JONATHAN RICKEL · 2002 to 2012
$9.3M
Development of a Thin-Film MicroECOG Electrode for Chronic Cortical RecordingsR01EB009103 · NIBIB · WASHINGTON UNIVERSITY · PI MORAN, DANIEL WILLIAM, WILLIAMS, JUSTIN COLE · 2008 to 2011
$2.0M
Validating Resting State fMRI Derived Brain ConnectivityRC1MH090912 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI MEYERAND, MARY E. · 2009 to 2010
$999k
Clinical Neuroengineering Training ProgramT32EB011434 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI MEYERAND, MARY E., PEARCE, ROBERT A · 2011 to 2015
$869k
Stroke PlasticityK23NS086852 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI PRABHAKARAN, VIVEK · 2014 to 2017
$749k
American Heart Association (American Heart Association, Inc.) 1T32EB011434-01A1NCATS NIH HHS UL1 TR000427NIBIB NIH HHS R01 EB000856NIBIB NIH HHS R01 EB009103NIBIB NIH HHS T32 EB011434NIGMS NIH HHS T32 GM008692NIMH NIH HHS RC1 MH090912NINDS NIH HHS K23 NS086852United States Department of Defense | Defense Advanced Research Projects Agency (DARPA) RCI Program MTO, N66001-12-C-4025, HIST Program MTO, N66001-11-1-4013;
6 · The paper itself

Abstract

Functional magnetic resonance imaging (fMRI)-based functional connectivity (FC) commonly characterizes the functional connections in the brain. Conventional quantification of FC by Pearson's correlation captures linear, time-domain dependencies among blood-oxygen-level-dependent (BOLD) signals. We examined measures to quantify FC by investigating: (i) Is Pearson's correlation sufficient to characterize FC? (ii) Can alternative measures better quantify FC? (iii) What are the implications of using alternative FC measures? FMRI analysis in healthy adult population suggested that: (i) Pearson's correlation cannot comprehensively capture BOLD inter-dependencies. (ii) Eight alternative FC measures were similarly consistent between task and resting-state fMRI, improved age-based classification and provided better association with behavioral outcomes. (iii) Formulated hypotheses were: first, in lieu of Pearson's correlation, an augmented, composite and multi-metric definition of FC is more appropriate; second, canonical large-scale brain networks may depend on the chosen FC measure. A thorough notion of FC promises better understanding of variations within a given population.

Indexed as

ConnectomeMagnetic Resonance ImagingNerve NetAdolescentAdultFemaleHumansMaleOxygenOxygen

Identifiers

PMID31992762
PMCPMC6987226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.