Evidence map›Paper›PMID 31992706›Full record

ArticleNature communications2020

TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential.

Hanzhi Zhang, Yaping Pan, Liya Hu, M Ashley Hudson, Katrina S Hofstetter, Zhichun Xu, Mingqiang Rong, Zhao Wang, B V Venkataram Prasad, Steve W Lockless and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Ecological plasticity ofMicrobiology spectrum · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Bacterial cell volume regulation and the importance of cyclic di-AMP.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  8. Structure and mechanism of the KNature communications · 2024
    Article
  9. The polyextremophileApplied and environmental microbiology · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Isolation and Genomics ofMicrobiology spectrum · 2023
    Article
  16. Review
  17. Article
  18. TrkA serves as a virulence modulator inFrontiers in cellular and infection microbiology · 2022
    Article
  19. Article
  20. Unappreciated Roles for KTrends in microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Hanzhi ZhangVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Yaping PanVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Liya HuVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-8340-8911
M Ashley HudsonDepartment of Biology, Texas A&M University, College Station, TX, 77843, USA.
Katrina S HofstetterDepartment of Biology, Texas A&M University, College Station, TX, 77843, USA.
Zhichun XuVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Mingqiang RongVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Zhao WangVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0003-4897-9986
B V Venkataram PrasadVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-1172-2071
Steve W LocklessDepartment of Biology, Texas A&M University, College Station, TX, 77843, USA. lockless@bio.tamu.edu.
Wah ChiuDepartments of Bioengineering and of Microbiology and Immunology, Stanford University, Stanford, CA, 94305, USA. wahc@stanford.edu.
Ming ZhouVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA. mzhou@bcm.edu.
Baylor College of Medicine · USTexas A&M University · USStanford University · US

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
3 D ELECTRON MICROSCOPY OF MACROMOLECULES (5P41RR002250-27)P41GM103832 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH · 2012 to 2019
$15.1M
Structural mechanism of K channel modulation by cellular redox stateR01HL086392 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZHOU, MING · 2006 to 2018
$3.9M
Structure and mechanism of mammalian stearoyl-CoA desaturasesR01DK122784 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI TSAI, AH-LIM, ZHOU, MING · 2019 to 2023
$3.2M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
Physiological Role for Cation Channels in BacteriaR01GM132436 · NIGMS · TEXAS A&M UNIVERSITY · PI SIEGELE, DEBORAH A. · 2019 to 2022
$1.6M
Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) R1223NCRR NIH HHS S10 RR029205NHLBI NIH HHS R01 HL086392NIDDK NIH HHS R01 DK122784NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P41 GM103832NIGMS NIH HHS R01 GM132436NIH HHS S10 OD021527U.S. Department of Health & Human Services | National Institutes of Health (NIH) GM098878U.S. Department of Health & Human Services | National Institutes of Health (NIH) GM119396U.S. Department of Health & Human Services | National Institutes of Health (NIH) HL086392U.S. Department of Health & Human Services | National Institutes of Health (NIH) P41GM103832
6 · The paper itself

Abstract

TrkH is a bacterial ion channel implicated in K

Indexed as

Adenosine DiphosphateAdenosine TriphosphateATP-Binding Cassette TransportersBacterial ProteinsBiological TransportEscherichia coliEscherichia coli ProteinsMembrane PotentialsModels, MolecularMutagenesisPotassiumPotassium ChannelsProtein ConformationProtein Interaction Domains and MotifsSequence DeletionVibrio parahaemolyticusAdenosine DiphosphateAdenosine TriphosphateATP-Binding Cassette TransportersBacterial ProteinsEscherichia coli ProteinsPotassiumPotassium ChannelsTrkA protein, E coliTrkH protein, E coli

Identifiers

PMID31992706
PMCPMC6987127
OpenAlexW3004297519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.