ArticleProceedings of the National Academy of Sciences of the United States of America2020
Conservative and disruptive modes of adolescent change in human brain functional connectivity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.
- Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.Nature communications · 2022Pooled it
- Bayesian dynamical system analysis of the effects of methylphenidate in children with attention-deficit/hyperactivity disorder: a randomized trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Developmental variation in resting-state EEG spectral correlates of response inhibition in children and adolescents.Developmental cognitive neuroscience · 2026Article
- Being praised and criticized in adolescents and adults: Age-related changes in neural responses to social evaluations.Developmental cognitive neuroscience · 2026Article
- Longitudinal Associations of Structural and Functional Brain Connectivity With Dimensions of Psychopathology in Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Contextualizing the adolescent social brain: Links to social health using data from the Adolescent Brain Cognitive Development Study.Developmental cognitive neuroscience · 2026Article
- Nucleus-level thalamic organization anchors multimodal signatures of thalamocortical maturation.bioRxiv : the preprint server for biology · 2026Article
- Transdiagnostic divergent neural development of reward anticipation in early adolescents at risk for depression and psychosis.Developmental cognitive neuroscience · 2026Article
- Regional reconfiguration of functional brain networks during childhood and adolescence: evaluating age and sex effect.bioRxiv : the preprint server for biology · 2026Article
- Mapping Individualized Developmental Imbalance in Youth and Its Association with Psychopathology.bioRxiv : the preprint server for biology · 2026Article
- Transforming Intracerebral Hemorrhage Care with Artificial Intelligence: Opportunities, Challenges, and Future Directions.Diagnostics (Basel, Switzerland) · 2026Review
- The contributions of biological maturity and experience to fine motor development in adolescence.Scientific reports · 2026Article
- Altered Dynamic Functional Network Connectivity in Post-Stroke Aphasia.Annals of clinical and translational neurology · 2026Article
- Aligning social media design with adolescent brain development: rationale and recommendations.Frontiers in digital health · 2026Article
- Multivariate environmental exposures are reflected in whole-brain functional connectivity and cognition in youth.bioRxiv : the preprint server for biology · 2025Article
- Identification and External Validation of a Problem Cannabis Risk Network.Biological psychiatry · 2025Article
- Molecular mechanisms explaining sex-specific functional connectivity changes in chronic insomnia disorder.BMC medicine · 2025Article
- Long-Term Exposure to Traffic-Related Air Pollution and Noise and Dynamic Brain Connectivity across Adolescence.Environmental health perspectives · 2025Article
- Multimodal evidence for cerebellar influence on cortical development in autism: structural growth amidst functional disruption.Molecular psychiatry · 2025Article
- Functional Brain Connectivity Predictors of Prospective Substance Use Initiation and Their Environmental Correlates.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
Adolescent changes in human brain function are not entirely understood. Here, we used multiecho functional MRI (fMRI) to measure developmental change in functional connectivity (FC) of resting-state oscillations between pairs of 330 cortical regions and 16 subcortical regions in 298 healthy adolescents scanned 520 times. Participants were aged 14 to 26 y and were scanned on 1 to 3 occasions at least 6 mo apart. We found 2 distinct modes of age-related change in FC: "conservative" and "disruptive." Conservative development was characteristic of primary cortex, which was strongly connected at 14 y and became even more connected in the period from 14 to 26 y. Disruptive development was characteristic of association cortex and subcortical regions, where connectivity was remodeled: connections that were weak at 14 y became stronger during adolescence, and connections that were strong at 14 y became weaker. These modes of development were quantified using the maturational index (MI), estimated as Spearman's correlation between edgewise baseline FC (at 14 y, [Formula: see text]) and adolescent change in FC ([Formula: see text]), at each region. Disruptive systems (with negative MI) were activated by social cognition and autobiographical memory tasks in prior fMRI data and significantly colocated with prior maps of aerobic glycolysis (AG), AG-related gene expression, postnatal cortical surface expansion, and adolescent shrinkage of cortical thickness. The presence of these 2 modes of development was robust to numerous sensitivity analyses. We conclude that human brain organization is disrupted during adolescence by remodeling of FC between association cortical and subcortical areas.
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