ArticleProceedings of the National Academy of Sciences of the United States of America2020
Histamine receptor agonist alleviates severe cardiorenal damages by eliciting anti-inflammatory programming.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Causal effects of gut microbiota on diabetic kidney disease: insights from 16S rRNA sequencing and bidirectional Mendelian randomization.Renal failure · 2025Article
- Histamine regulates the activity and the expression of the NaInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Cardiorenal damages in mice at early phase after intervention induced by angiotensin II, nephrectomy, and salt intake.Experimental animals · 2024Article
- Combination of sacubitril/valsartan and blockade of the PI3K pathway enhanced kidney protection in a mouse model of cardiorenal syndrome.European heart journal open · 2023Article
- Recovery of the histamine HScientific reports · 2023Article
- Renal histaminergic system and acute effects of histamine receptor 2 blockade on renal damage in the Dahl salt-sensitive rat.American journal of physiology. Renal physiology · 2023Article
- Histamine receptors in heart failure.Heart failure reviews · 2022Review
- Emerging cardioprotective mechanisms of vitamin B6: a narrative review.European journal of nutrition · 2022Review
- Analysis of Immune Associated Co-Expression Networks Reveals Immune-Related Long Non-Coding RNAs during MI in the Presence and Absence of HDC.International journal of molecular sciences · 2021Article
- The implications of histamine metabolism and signaling in renal function.Physiological reports · 2021Review
- Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles.Scientific reports · 2020Article
- Histamine and histidine decarboxylase: Immunomodulatory functions and regulatory mechanisms.Genes to cells : devoted to molecular & cellular mechanisms · 2020Review
- Histamine provides an original vista on cardiorenal syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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14 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Heart failure and chronic kidney disease are major causes of morbidity and mortality internationally. Although these dysfunctions are common and frequently coexist, the factors involved in their relationship in cardiorenal regulation are still largely unknown, mainly due to a lack of detailed molecular targets. Here, we found the increased plasma histamine in a preclinical mouse model of severe cardiac dysfunction, that had been cotreated with angiotensin II (Ang II), nephrectomy, and salt (ANS). The ANS mice exhibited impaired renal function accompanied with heart failure, and histamine depletion, by the genetic inactivation of histidine decarboxylase in mice, exacerbated the ANS-induced cardiac and renal abnormalities, including the reduction of left ventricular fractional shortening and renal glomerular and tubular injuries. Interestingly, while the pharmacological inhibition of the histamine receptor H3 facilitated heart failure and kidney injury in ANS mice, administration of the H3 agonist immethridine (Imm) was protective against cardiorenal damages. Transcriptome analysis of the kidney and biochemical examinations using blood samples illustrated that the increased inflammation in ANS mice was alleviated by Imm. Our results extend the pharmacological use of H3 agonists beyond the initial purposes of its drug development for neurogenerative diseases and have implications for therapeutic potential of H3 agonists that invoke the anti-inflammatory gene expression programming against cardiorenal damages.
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