ArticleProceedings of the National Academy of Sciences of the United States of America2020
Mapping proteome-wide targets of protein kinases in plant stress responses.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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85 citing papers in PubMed, 176 citations in OpenAlex.
- Evolutionary tuning of the molecular charge state of UBP24 shapes responses to high temperature.Nature plants · 2026Article
- Mapping the dynamic plant interactome: from in vitro assays to in vivo quantitative approaches.Plant methods · 2026Review
- Genetic analyses of autoimmune mutants uncover the MPK3/6-CHR5-SNC1 module in Arabidopsis.Scientific reports · 2026Article
- Arabidopsis OST1 homologs of barley are involved in stomatal regulation.Journal of experimental botany · 2026Article
- Masters of perception: phosphorylation-dependent signaling in plants.The New phytologist · 2026Review
- OsCPK9-mediated Thr105 phosphorylation activates OsCATC to enhance drought tolerance in rice.Journal of advanced research · 2026Article
- Proteome and Phosphoproteome of Tomato Fruit Identify REDUCED CHLOROPLAST COVERAGE 1a as A Ripening Regulator.Genomics, proteomics & bioinformatics · 2025Article
- MAP4K1 and MAP4K2 regulate ABA-induced and CaScience advances · 2025Article
- Osmotic stress triggers calcium-mediated expression of the aquaporin (TIP2;1) gene in ashwagandha (Withania somnifera L. Dunal).Molecular biology reports · 2025Article
- Transcriptomic profiling to investigate the therapeutic potential and medicinal properties of Momordica cymbalaria.Scientific reports · 2025Article
- Whole genome sequencing reveals transcriptional and translational elements potentially regulating biotic and abiotic stress responses in cowpea.Scientific reports · 2025Article
- B4 Raf-like MAPKKK RAF24 regulates Arabidopsis thaliana flowering time through HISTONE MONO-UBIQUITINATION 2.The New phytologist · 2025Article
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- SnRK2s: Kinases or Substrates?Plants (Basel, Switzerland) · 2025Review
- Genome-Wide Analysis ofInternational journal of molecular sciences · 2025Article
- Salt stress activates the CDK8-AHL10-SUVH2/9 module to dynamically regulate salt tolerance in Arabidopsis.Nature communications · 2025Article
- Phosphoproteomic Analysis of Maize Seedlings Provides Insights into the Mechanisms of Heat-Stress Tolerance.International journal of molecular sciences · 2025Article
- Plant intelligence dux: a comprehensive rebuttal of Kingsland and Taiz.Protoplasma · 2025Article
- Salinity survival: molecular mechanisms and adaptive strategies in plants.Frontiers in plant science · 2025Review
- Multi-locus GWAS analysis identifies genomic regions associated with resistance to ergot (Claviceps africana) in sorghum.PloS one · 2025Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Protein kinases are major regulatory components in almost all cellular processes in eukaryotic cells. By adding phosphate groups, protein kinases regulate the activity, localization, protein-protein interactions, and other features of their target proteins. It is known that protein kinases are central components in plant responses to environmental stresses such as drought, high salinity, cold, and pathogen attack. However, only a few targets of these protein kinases have been identified. Moreover, how these protein kinases regulate downstream biological processes and mediate stress responses is still largely unknown. In this study, we introduce a strategy based on isotope-labeled in vitro phosphorylation reactions using in vivo phosphorylated peptides as substrate pools and apply this strategy to identify putative substrates of nine protein kinases that function in plant abiotic and biotic stress responses. As a result, we identified more than 5,000 putative target sites of osmotic stress-activated SnRK2.4 and SnRK2.6, abscisic acid-activated protein kinases SnRK2.6 and casein kinase 1-like 2 (CKL2), elicitor-activated protein kinase CDPK11 and MPK6, cold-activated protein kinase MPK6, H
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.