Evidence map›Paper›PMID 31992630›Full record

ArticlemSystems2020

Effects of Antibiotic Pretreatment of an Ulcerative Colitis-Derived Fecal Microbial Community on the Integration of Therapeutic Bacteria

Kaitlyn Oliphant, Kyla Cochrane, Kathleen Schroeter, Michelle C Daigneault, Sandi Yen, Elena F Verdu, Emma Allen-Vercoe

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Tumor-Associated Microbiome: Where Do We Stand?International journal of molecular sciences · 2021
    Review
  7. Review
  8. Opposite regulatory effects ofFrontiers in neurology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kaitlyn OliphantDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada koliphan@uoguelph.ca.
Kyla CochraneDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
Kathleen SchroeterDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
Michelle C DaigneaultDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
Sandi YenDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
Elena F VerduDivision of Gastroenterology, Department of Medicine, Farncombe Family Digestive Health Institute, McMaster University, Hamilton, Ontario, Canada.
Emma Allen-VercoeDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
University of Guelph · CAMcMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fecal microbiota transplantation (FMT) is a proposedly useful strategy for the treatment of gastrointestinal (GI) disorders through remediation of the patient gut microbiota. However, its therapeutic success has been variable, necessitating research to uncover mechanisms that improve patient response. Antibiotic pretreatment has been proposed as one method to enhance the success rate by increasing niche availability for introduced species. Several limitations hinder exploring this hypothesis in clinical studies, such as deleterious side effects and the development of antimicrobial resistance in patients. Thus, the purpose of this study was to evaluate the use of an

Indexed as

antibiotic pretreatmentbioreactorfecal microbiota transplantationhuman gut microbiomein vitro modelmicrobial ecosystem therapeuticsrifaximin

Identifiers

PMID31992630
PMCPMC6989129
OpenAlexW3004229270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.