Evidence map›Paper›PMID 31992620›Full record

ArticlemBio2020

A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales Mucor circinelloides.

Sandeep Vellanki, R Blake Billmyre, Alejandra Lorenzen, Micaela Campbell, Broderick Turner, Eun Young Huh, Joseph Heitman, Soo Chan Lee

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
0.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Article
  3. Phagosome maturation during fungal infection.Current opinion in microbiology · 2026
    Review
  4. Article
  5. Yeasts in the gastrointestinal tract.FEMS yeast research · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Mucormycosis: A Rare disease to Notifiable Disease.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Review
  10. Molecular mechanisms that govern infection and antifungal resistance in Mucorales.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  11. Article
  12. AlternativeFrontiers in cellular and infection microbiology · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Differential Gene Expression ofJournal of fungi (Basel, Switzerland) · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sandeep VellankiSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA.
R Blake BillmyreDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Alejandra LorenzenSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA.
Micaela CampbellSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA.
Broderick TurnerSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA.
Eun Young HuhSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA.
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Soo Chan LeeSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA soochan.lee@utsa.edu.
Texas Center for Infectious Disease · USDuke University · USThe University of Texas at San Antonio · US

Funding

Trehalose Pathway for Antifungal Targets and InhibitorsP01AI104533 · NIAID · DUKE UNIVERSITY · PI BRENNAN, RICHARD GERALD · 2015 to 2019
$9.0M
Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
Improvement of genetic analysis in the pathogenic zygomycete Mucor circinelloidesR03AI119617 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI LEE, SOO CHAN · 2016 to 2017
$150k
NIAID NIH HHS P01 AI104533NIAID NIH HHS R01 AI050113NIAID NIH HHS R03 AI119617NIAID NIH HHS R37 AI039115
6 · The paper itself

Abstract

Mucormycosis is an emerging lethal fungal infection in immunocompromised patients.

Indexed as

Drug Resistance, FungalAntifungal AgentsCalcineurin InhibitorsFungal ProteinsGene Expression Regulation, FungalHost-Pathogen InteractionsHumansMicrobial Sensitivity TestsModels, BiologicalMucorMucormycosisMutationRNA, MessengerVirulenceVirulence FactorsAntifungal AgentsCalcineurin InhibitorsFungal ProteinsRNA, MessengerVirulence Factorsamino acid permeasecalcineurindimorphismdrug resistance mechanismsMucormucormycosisprotein kinase A

Identifiers

PMID31992620
PMCPMC6989107
OpenAlexW3003541267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.