Evidence map›Paper›PMID 31992595›Full record

ArticleThe Journal of biological chemistry2020

Antisense oligonucleotides targeting

Ernesto Canalis, Tamar R Grossman, Michele Carrer, Lauren Schilling, Jungeun Yu

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

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  9. Curative Cell and Gene Therapy for Osteogenesis Imperfecta.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ernesto CanalisDepartment of Orthopaedic Surgery, UConn Health, Farmington, Connecticut 06030 canalis@uchc.edu.ORCID 0000-0002-9154-952X
Tamar R GrossmanIonis Pharmaceuticals, Inc., Carlsbad, California 92010.
Michele CarrerIonis Pharmaceuticals, Inc., Carlsbad, California 92010.
Lauren SchillingUConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut 06030.
Jungeun YuDepartment of Orthopaedic Surgery, UConn Health, Farmington, Connecticut 06030.
UConn Health · USIonis Pharmaceuticals (United States) · US

Funding

Mechanisms of Notch Action in BoneR01DK045227 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CANALIS, ERNESTO · 1991 to 2018
$4.7M
Targeting the Notch3 Mutation to Cure Lehman SyndromeR61AR076747 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CANALIS, ERNESTO · 2019 to 2020
$799k
Targeting the Notch3 Mutation to Cure Lehman SyndromeR33AR076747 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CANALIS, ERNESTO · 2022 to 2022
$411k
NIAMS NIH HHS R33 AR076747NIAMS NIH HHS R61 AR076747NIDDK NIH HHS R01 DK045227
6 · The paper itself

Abstract

Notch receptors play critical roles in cell-fate decisions and in the regulation of skeletal development and bone remodeling. Gain-of-function

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsBone and BonesCell Cycle ProteinsDisease Models, AnimalFemaleHajdu-Cheney SyndromeMacrophagesMaleMiceMice, Inbred C57BLMice, TransgenicMuscle, SkeletalOligonucleotides, AntisenseOsteoclastsOsteogenesisBasic Helix-Loop-Helix ProteinsCell Cycle ProteinsHey1 protein, mouseHeyl protein, mouseNotch2 protein, mouseOligonucleotides, AntisenseRANK LigandReceptor, Notch2Tnfsf11 protein, mouseantisense oligonucleotidesbonebone resorptioncell fatecell signalingHajdu-Cheney syndromeNotch receptorosteoclastosteoclastogenesisosteoporosis

Identifiers

PMID31992595
PMCPMC7086019
OpenAlexW3003682200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.