Evidence map›Paper›PMID 31992591›Full record

ArticleRNA (New York, N.Y.)2020

The asymmetry and cooperativity of tandem glycine riboswitch aptamers.

Chad D Torgerson, David A Hiller, Scott A Strobel

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The current riboswitch landscape inMicrobiology (Reading, England) · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
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  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chad D TorgersonChemical Biology Institute, Yale University, West Haven, Connecticut 06516, USA.ORCID 0000-0002-9184-1141
David A HillerChemical Biology Institute, Yale University, West Haven, Connecticut 06516, USA.
Scott A StrobelChemical Biology Institute, Yale University, West Haven, Connecticut 06516, USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
X-RAY ANALYSIS OF PROTEIN STRUCTURE AND FUNCTIONP01GM022778 · NIGMS · YALE UNIVERSITY · PI BREAKER, RONALD R · 1985 to 2019
$26.1M
PREDOCTORAL PROGRAM IN BIOPHYSICST32GM008283 · NIGMS · YALE UNIVERSITY · PI XIONG, YONG · 1988 to 2022
$10.5M
NCATS NIH HHS UL1 TR001863NIGMS NIH HHS P01 GM022778NIGMS NIH HHS T32 GM008283
6 · The paper itself

Abstract

Glycine riboswitches utilize both single- and tandem-aptamer architectures. In the tandem system, the relative contribution of each aptamer toward gene regulation is not well understood. To dissect these contributions, the effects of 684 single mutants of a tandem ON switch from

Indexed as

Aptamers, NucleotideBacillus subtilisBinding SitesComputational BiologyGlycineLigandsMutationNucleic Acid ConformationRiboswitchRNA, BacterialVibrio choleraeAptamers, NucleotideGlycineLigandsRiboswitchRNA, Bacterialcooperativityglycineriboswitchtandemtranscription termination

Identifiers

PMID31992591
PMCPMC7161355
OpenAlexW3004236230

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.