Evidence map›Paper›PMID 31992387›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2020

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR.

Victor M Corman, Olfert Landt, Marco Kaiser, Richard Molenkamp, Adam Meijer, Daniel Kw Chu, Tobias Bleicker, Sebastian Brünink, Julia Schneider, Marie Luisa Schmidt and 14 more

RetractedErratum issued 5 registry-linked trialsAbstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. It is linked to 5 registered trials, which are not on this map. Cited by 4,177 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4,177citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04360954 completednot on this map

Evaluation of Commerical Antibody Tests for COVID-19

TypeobservationalSponsorWashington University School of MedicineRan2020 to 2020Enrolled461ConditionsCOVID, CoronavirusArmsDiagnostic test
NCT04723446 nacompletednot on this mapstarted 2021, after this paper: background citation

Efficacy of Three Antimicrobial Mouthwashes in Reducing SARS-CoV-2 Viral Load in the Saliva of Patients Diagnosed With COVID-19: A Pilot Study

TypeinterventionalSponsorQueen Mary University of LondonRan2021 to 2021Enrolled54ConditionsCovid19, CoronavirusArmsCorsodyl® Alcohol free -0.2 % Chlorhexidine digluconate, Colgate Peroxyl® -1.5% Hydrogen peroxide, Oral-B® Gum & Enamel Care -Cetylpyridinium chloride, No rinsing
NCT04750720 nacompletednot on this map

Study of the Kinetics of COVID-19 Antibodies for 24 Months in Patients With Confirmed SARS-CoV-2 Infection According to the Clinical Severity of the Infection.

TypeinterventionalSponsorCentre Hospitalier Régional d'OrléansRan2020 to 2022Enrolled187ConditionsCovid19, SARS-CoV-2ArmsSampling by venipuncture (and eventually by nasopharyngeal swab)
NCT05311410 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Viral Kinetics of SARS-CoV-2 in Patients in the Intensive Care Unit Undergoing Dental Procedures

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2021 to 2025Enrolled60ConditionsSARS-CoV2 Infection, Viral Load, Oral Diseases, Dental TreatmentArmsNon-bloody dental procedures (control group), Bloody dental procedures (study group)
NCT05507671 phase3active not recruitingnot on this mapstarted 2021, after this paper: background citation

The Role of the Bacillus Calmette-Guérin Vaccine (BCG) in the Clinical Evolution of COVID-19 and in the Efficacy of Anti-SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) Vaccines

TypeinterventionalSponsorOswaldo Cruz FoundationRan2021 to 2025Enrolled556ConditionsCOVID-19ArmsBCG (Bacillus Calmette-Guérin) vaccine, Placebo
3 · Its place in the literature

Who cites it

4,177 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Improving public health laboratory preparedness at European Union level: learning points from experiences during the COVID-19 pandemic.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
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4,117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Victor M CormanCharité - Universitätsmedizin Berlin Institute of Virology, Berlin, Germany and German Centre for Infection Research (DZIF), Berlin, Germany.
Olfert LandtTib-Molbiol, Berlin, Germany.
Marco KaiserGenExpress GmbH, Berlin, Germany.
Richard MolenkampDepartment of Viroscience, Erasmus MC, Rotterdam, the Netherlands.
Adam MeijerNational Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Daniel Kw ChuUniversity of Hong Kong, Hong Kong, China.
Tobias BleickerCharité - Universitätsmedizin Berlin Institute of Virology, Berlin, Germany and German Centre for Infection Research (DZIF), Berlin, Germany.
Sebastian BrüninkCharité - Universitätsmedizin Berlin Institute of Virology, Berlin, Germany and German Centre for Infection Research (DZIF), Berlin, Germany.
Julia SchneiderCharité - Universitätsmedizin Berlin Institute of Virology, Berlin, Germany and German Centre for Infection Research (DZIF), Berlin, Germany.
Marie Luisa SchmidtCharité - Universitätsmedizin Berlin Institute of Virology, Berlin, Germany and German Centre for Infection Research (DZIF), Berlin, Germany.
Daphne Gjc MuldersDepartment of Viroscience, Erasmus MC, Rotterdam, the Netherlands.
Bart L HaagmansDepartment of Viroscience, Erasmus MC, Rotterdam, the Netherlands.
Bas van der VeerNational Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Sharon van den BrinkNational Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Lisa WijsmanNational Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Gabriel GoderskiNational Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Jean-Louis RometteUniversite d Aix-Marseille, Marseille, France.
Joanna EllisPublic Health England, London, United Kingdom.
Maria ZambonPublic Health England, London, United Kingdom.
Malik PeirisUniversity of Hong Kong, Hong Kong, China.
Herman GoossensDepartment of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium.
Chantal ReuskenNational Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Marion Pg KoopmansDepartment of Viroscience, Erasmus MC, Rotterdam, the Netherlands.
Christian DrostenCharité - Universitätsmedizin Berlin Institute of Virology, Berlin, Germany and German Centre for Infection Research (DZIF), Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for public health laboratories as virus isolates are unavailable while there is growing evidence that the outbreak is more widespread than initially thought, and international spread through travellers does already occur.

aimWe aimed to develop and deploy robust diagnostic methodology for use in public health laboratory settings without having virus material available.

methodsHere we present a validated diagnostic workflow for 2019-nCoV, its design relying on close genetic relatedness of 2019-nCoV with SARS coronavirus, making use of synthetic nucleic acid technology.

resultsThe workflow reliably detects 2019-nCoV, and further discriminates 2019-nCoV from SARS-CoV. Through coordination between academic and public laboratories, we confirmed assay exclusivity based on 297 original clinical specimens containing a full spectrum of human respiratory viruses. Control material is made available through European Virus Archive - Global (EVAg), a European Union infrastructure project.

conclusionThe present study demonstrates the enormous response capacity achieved through coordination of academic and public laboratories in national and European research networks.

Indexed as

Clinical Laboratory TechniquesCoronavirusCoronavirus InfectionsCOVID-19 TestingCOVID-19 VaccinesDisease OutbreaksHumansReal-Time Polymerase Chain ReactionRNA, ViralSensitivity and SpecificityCovid-19 aAPC vaccineCOVID-19 VaccinesRNA, Viral2019-nCoVdiagnosticslaboratorynovel coronavirusoutbreakRT-PCRtestingWuhan

Identifiers

PMID31992387
PMCPMC6988269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.