Evidence map›Paper›PMID 31992347›Full record

ArticleOrphanet journal of rare diseases2020

Depressive symptoms in Fabry disease: the importance of coping, subjective health perception and pain.

Simon Körver, Gert J Geurtsen, Carla E M Hollak, Ivo N van Schaik, Maria G F Longo, Marjana R Lima, Leonardo Vedolin, Marcel G W Dijkgraaf, Mirjam Langeveld

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orphanet journal of rare diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Simon KörverDepartment of Endocrinology and Metabolism, Amsterdam UMC, location AMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.ORCID 0000-0003-1432-7760
Gert J GeurtsenDepartment of Medical Psychology, Amsterdam UMC, location AMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
Carla E M HollakDepartment of Endocrinology and Metabolism, Amsterdam UMC, location AMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
Ivo N van SchaikDepartment of Neurology, Amsterdam UMC, location AMC, University of Amsterdam, Meibergdreef 9, Amsterdam, Spaarne Gasthuis, Haarlem, The Netherlands.
Maria G F LongoDepartment of Radiology, Massachusetts General Hospital, Boston, MA, USA.
Marjana R LimaDepartment of Radiology, Hospital Moinhos de Vento, Porto Alegre, Brazil.
Leonardo VedolinImaging Director, Diagnóstico da América SA, Sao Paulo, Brazil.
Marcel G W DijkgraafDepartment of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, location AMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
Mirjam LangeveldDepartment of Endocrinology and Metabolism, Amsterdam UMC, location AMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands. m.langeveld@amsterdamumc.nl.
Amsterdam University Medical Centers · NLCentrus Diagnósticos por Imagem · BRHospital Moinhos de Vento · BRMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the high prevalence of depressive symptoms in Fabry disease (FD), it is unclear which patient characteristics are important in relation to these symptoms. Additionally, the impact of coping styles in relation to depressive symptoms in FD has been unexplored. Determining the impact of different factors relating to depressive symptoms in FD can guide both prevention and treatment of these symptoms.

methodsDepressive symptoms (Center for Epidemiologic Studies Depression scale (CESD)) and coping styles (Utrecht Coping List) were assessed in a Dutch FD cohort. Other potentially important variables were identified from FD literature and assessed in this cohort. Relations were evaluated using multiple linear models.

resultsPotentially important variables in FD literature were: pain, unemployment, health perception, being single, comorbidities and stroke. Employed coping styles were "avoidance and brooding", "positivity and problem solving" and "seeking social support". Thirty-one of the 81 FD patients (38%) had depressive symptoms. CESD-scores were lower in patients with better health perception and more "positivity and problem solving" and higher in patients with more pain and "avoidance and brooding". The best model explained 70% (95%CI: 54-76%) of observed variance of the CESD.

conclusionsDepressive symptoms in FD are related to pain, negative health perception and use of specific coping styles. Psychological interventions could be employed to alter coping behavior and alleviate depressive symptoms.

Indexed as

AdultAgedBrainDepressionFabry DiseaseFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPainSurveys and QuestionnairesCopingDepressionDepressive symptomsFabry diseaseHealth perceptionPain

Identifiers

PMID31992347
PMCPMC6986064
OpenAlexW3008883603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.