Evidence map›Paper›PMID 31992292›Full record

ArticleRespiratory research2020

Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy.

Michael J McGeachie, Joanne E Sordillo, Amber Dahlin, Alberta L Wang, Sharon M Lutz, Kelan G Tantisira, Ronald Panganiban, Quan Lu, Satria Sajuthi, Cydney Urbanek and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Pharmacogenetics of childhood uncontrolled asthma.Expert review of clinical immunology · 2025
    Review
  2. Article
  3. Article
  4. Review
  5. Gene-environment interactions in childhood asthma revisited; expanding the interaction concept.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 6 institutions in 2 countries.

Michael J McGeachieChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5566-2712
Joanne E SordilloPRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, 401 Park Drive, Suite 401, Boston, MA, 02215-5301, USA.
Amber DahlinChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Alberta L WangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Sharon M LutzPRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, 401 Park Drive, Suite 401, Boston, MA, 02215-5301, USA.
Kelan G TantisiraChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Ronald PanganibanProgram in Molecular and Integrative Physiological Sciences, Departments of Environmental Health and Genetics & Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Quan LuProgram in Molecular and Integrative Physiological Sciences, Departments of Environmental Health and Genetics & Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Satria SajuthiCenter for Genes, Environment and Health, Department of Pediatrics, National Jewish Health, Denver, CO, USA.
Cydney UrbanekCenter for Genes, Environment and Health, Department of Pediatrics, National Jewish Health, Denver, CO, USA.
Rachel KellyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Benjamin SaefCenter for Genes, Environment and Health, Department of Pediatrics, National Jewish Health, Denver, CO, USA.
Celeste EngDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Sam S OhDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Alvin T KhoComputational Health Informatics Program, Boston Children's Hospital, Boston, MA, USA.
Damien C Croteau-ChonkaChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Scott T WeissChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Benjamin A RabyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Angel C Y MakCenter for Genes, Environment and Health, Department of Pediatrics, National Jewish Health, Denver, CO, USA.
Jose R Rodriguez-SantanaCentro de Neumologia Pediatrica, San Juan, PR, USA.
Esteban G BurchardCenter for Genes, Environment and Health, Department of Pediatrics, National Jewish Health, Denver, CO, USA.
Max A SeiboldDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Ann Chen WuPRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, 401 Park Drive, Suite 401, Boston, MA, 02215-5301, USA. ann.wu@childrens.harvard.edu.
Brigham and Women's Hospital · USNational Jewish Health · USHarvard University · USUniversity of California, San Francisco · USBoston Children's Hospital · USCentro de Neumologia Pediatrica · PR

Funding

THE PHARMACOGENETICS OF ASTHMA TREATMENTU01HL065899 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G, WEISS, SCOTT T · 2000 to 2014
$38.5M
The Asthma BioRepository for Integrative Genomics ResearchRC2HL101543 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI RABY, BENJAMIN ALEXANDER, WEISS, SCOTT T · 2009 to 2010
$8.3M
The Integrative Genomics of Acute Asthma ControlR01HL118455 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MILLSTEIN, JOSHUA, RABY, BENJAMIN ALEXANDER · 2014 to 2024
$6.5M
Asthma Exacerbations and MicroRNA prediction: Treatment Response in an Underserved Ethnicity (AEM-TRUE)R01HL139634 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MCGEACHIE, MICHAEL JOHN · 2018 to 2022
$4.3M
Transcriptomic and Pharmacogenetic Asthma Endotypes in Minority ChildrenR01HL135156 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A, ZIV, ELAD · 2017 to 2021
$4.1M
MICRORNAS AND EARLY LIFE EXPOSURES IN THE DEVELOPMENTAL ORIGIN OF ASTHMAR01HL125734 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SHARMA, SUNITA · 2016 to 2020
$3.5M
MICRORNAS IN CIRCULATION: ONTOLOGIES OF ASTHMA SEVERITY AND TREATMENT (MICROCOAST)R01HL127332 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2015 to 2018
$3.4M
Age-Dependent Pharmacogenomics of Asthma Treatment (ADAPT)R01HD085993 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI WU, ANN CHEN · 2016 to 2020
$3.1M
DISEASE AND HEALTH: ASTHMA RESILIENCE THROUGH MICRORNA ATTRIBUTES (DHARMA)R01HL129935 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2015 to 2017
$1.4M
GENOMICS AND PHARMACOGENOMICS OF SYMPTOMS IN ASTHMAR01NR013391 · NINR · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2011 to 2013
$1.3M
Multi-Omic Endotyping of AsthmaK01HL146980 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KELLY, RACHEL SABINE · 2019 to 2023
$891k
Weight loss-induced modification of the genomic network underlying obese asthmaK01HL127265 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CROTEAU-CHONKA, DAMIEN C. · 2015 to 2019
$844k
NHLBI NIH HHS K01 HL125858NHLBI NIH HHS K01 HL127265NHLBI NIH HHS K01 HL130629NHLBI NIH HHS K01 HL146980NHLBI NIH HHS R00 HL109162NHLBI NIH HHS R01 HL118455NHLBI NIH HHS R01 HL125734NHLBI NIH HHS R01 HL127332NHLBI NIH HHS R01 HL129935NHLBI NIH HHS R01 HL135156NHLBI NIH HHS R01 HL139634NHLBI NIH HHS RC2 HL101543NHLBI NIH HHS U01 HL065899NICHD NIH HHS R01 HD085993NIH HHS K01 HL127265NIH HHS R00 HL109162NIH HHS R01HL118455NIH HHS R01 HL139634NIH HHS RC2 HL101543NINR NIH HHS R01 NR013391
6 · The paper itself

Abstract

backgroundGlobal gene expression levels are known to be highly dependent upon gross demographic features including age, yet identification of age-related genomic indicators has yet to be comprehensively undertaken in a disease and treatment-specific context.

methodsWe used gene expression data from CD4+ lymphocytes in the Asthma BioRepository for Integrative Genomic Exploration (Asthma BRIDGE), an open-access collection of subjects participating in genetic studies of asthma with available gene expression data. Replication population participants were Puerto Rico islanders recruited as part of the ongoing Genes environments & Admixture in Latino Americans (GALA II), who provided nasal brushings for transcript sequencing. The main outcome measure was chronic asthma control as derived by questionnaires. Genomic associations were performed using regression of chronic asthma control score on gene expression with age in years as a covariate, including a multiplicative interaction term for gene expression times age.

resultsThe SMARCD1 gene (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1) interacted with age to influence chronic asthma control on inhaled corticosteroids, with a doubling of expression leading to an increase of 1.3 units of chronic asthma control per year (95% CI [0.86, 1.74], p = 6 × 10

conclusionFocusing on age-dependent factors may help identify novel indicators of asthma medication response. Age appears to modulate the effect of SMARCD1 on asthma control with inhaled corticosteroids.

Indexed as

Administration, InhalationAdolescentAdrenal Cortex HormonesAdultAge FactorsAsthmaChildChromosomal Proteins, Non-HistoneCohort StudiesFemaleGene ExpressionHispanic or LatinoHumansMaleMiddle AgedTreatment OutcomeAdrenal Cortex HormonesChromosomal Proteins, Non-HistoneSMARCD1 protein, human

Identifiers

PMID31992292
PMCPMC6988322
OpenAlexW3013995385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.