ArticleBMC neurology2020
Abnormal blood pressure circadian rhythms are relevant to cerebral infarction and Leukoaraiosis in hypertensive patients.
Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Baseline systolic blood pressure, hypertension history, and efficacy of remote ischemic conditioning.Annals of clinical and translational neurology · 2024Trial
- The association between ambulatory blood pressure monitoring and 90-day ischemic stroke following transient ischemic attack in hypertensive patients: a retrospective cohort study.BMC neurology · 2026Article
- Controversies in hypertension therapy: bedtime dosing or daytime dosing?Journal of hypertension · 2025Review
- Risk of acute cerebral infarction in patients with hypertension based on high-resolution MRI.Quantitative imaging in medicine and surgery · 2025Article
- Association of reverse dipping blood pressure with mortality among critically ill patients with ischemic stroke.Internal and emergency medicine · 2025Article
- Impact of blood pressure variability and cerebral small vessel disease: A systematic review and meta-analysis.Heliyon · 2024Article
- Article
- Astrocyte-Neuronal Communication and Its Role in Stroke.Neurochemical research · 2023Review
- Risk factors of acute cerebral infarction in patients with primary hypertension.Irish journal of medical science · 2023Article
- The Regulation of miR-206 on BDNF: A Motor Function Restoration Mechanism Research on Cerebral Ischemia Rats by Meridian Massage.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Higher Burden of Cerebral Small Vascular Disease Predicts Major Adverse Cardiac and Cerebrovascular Events and Is Related to Abnormal Blood Pressure Variability Pattern in Hypertension Patients.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTo investigate the relationships between blood pressure (BP) circadian rhythms and acute cerebral infarction (ACI), silent cerebral infarction (SCI) and the severity of leukoaraiosis in hypertensive patients.
methodsA retrospective case-control study was performed among hypertensive patients with 24-h ambulatory blood pressure monitoring (ABPM) and cranial magnetic resonance imaging (MRI).
resultsA total of 1267 patients were enrolled. Lower nocturnal blood pressure (BP) decreases were observed in ACI patients than in controls (3.3% vs 8.2%, P<0.001). Reverse-dipper pattern (RD) and non-dipper pattern (ND) were found to be independent risk factors for ACI. In ACI patients, both RD and ND BP circadian rhythms were revealed to be independent risk factors for moderate-severe leukoaraiosis. In addition, in SCI patients, RD (OR = 1.7, 95% CI, 0.9-3.0; P = 0.047) or extreme-dipper pattern (ED) (OR = 2.9, 95% CI, 1.2-7.0; P = 0.015) were found to be independent risk factors for moderate-severe leukoaraiosis. Moreover, the greater the severity of leukoaraiosis was, the higher the ratio of abnormal BP circadian rhythms.
conclusionRD and ND BP circadian rhythms might not only be relevant to the onset of ACI but also correlate with the severity of leukoaraiosis. Thus, when modulating BP with antihypertensive drugs, the BP circadian rhythms, and not merely the BP level, should warrant more attention.
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