Evidence map›Paper›PMID 31992121›Full record

ArticleEpigenetics

Epigenomics of being bullied: changes in DNA methylation following bullying exposure.

Rosa H Mulder, Esther Walton, Alexander Neumann, Lotte C Houtepen, Janine F Felix, Marian J Bakermans-Kranenburg, Matthew Suderman, Henning Tiemeier, Marinus H van IJzendoorn, Caroline L Relton and 1 more

Abstract read
In one paragraph

Article in Epigenetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  6. DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study.Journal of child psychology and psychiatry, and allied disciplines · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rosa H MulderInstitute of Education and Child Studies, Leiden University , Leiden, The Netherlands.
Esther WaltonMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol , Bristol, UK.
Alexander NeumannDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center Rotterdam , Rotterdam, The Netherlands.ORCID 0000-0001-6653-3203
Lotte C HoutepenMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol , Bristol, UK.ORCID 0000-0003-1442-8852
Janine F FelixGeneration R Study Group, Erasmus MC, University Medical Center Rotterdam , Rotterdam, The Netherlands.
Marian J Bakermans-KranenburgClinical Child & Family Studies, Vrije Universiteit Amsterdam , Amsterdam, The Netherlands.ORCID 0000-0001-7763-0711
Matthew SudermanMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol , Bristol, UK.
Henning TiemeierDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center Rotterdam , Rotterdam, The Netherlands.
Marinus H van IJzendoornDepartment of Psychology, Education and Child Studies, Erasmus University Rotterdam , Rotterdam, The Netherlands.ORCID 0000-0003-1144-454X
Caroline L ReltonMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol , Bristol, UK.
Charlotte A M CecilDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center Rotterdam , Rotterdam, The Netherlands.

Funding

Epigenetic Pathways to Conduct Problem Trajectories: Early Environmental RisksR01HD068437 · NICHD · KING'S COLLEGE LONDON · PI BARKER, EDWARD D., MILL, JONATHAN · 2012 to 2014
$1.1M
Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_12013/2NICHD NIH HHS R01 HD068437Wellcome Trust
6 · The paper itself

Abstract

Bullying among children is ubiquitous and associated with pervasive mental health problems. However, little is known about the biological pathways that change after exposure to bullying. Epigenome-wide changes in DNA methylation in peripheral blood were studied from pre- to post measurement of bullying exposure, in a longitudinal study of the population-based Generation R Study and Avon Longitudinal Study of Parents and Children (combined

Indexed as

BullyingDNA MethylationEpigenomeAdolescentChildCpG IslandsFemaleHumansMalerab GTP-Binding ProteinsReceptors, GlucocorticoidSerotonin Plasma Membrane Transport ProteinsNR3C1 protein, humanRab14 protein, humanrab GTP-Binding ProteinsReceptors, GlucocorticoidSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, humanALSPACbullyingDNA methylationEWASGeneration RIllumina 450Klongitudinalpeer victimization

Identifiers

PMID31992121
PMCPMC7574379

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.