Evidence map›Paper›PMID 31992093›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2020

C-2 phenyl replacements to obtain potent quinoline-based

Tommaso Felicetti, Gianmarco Mangiaterra, Rolando Cannalire, Nicholas Cedraro, Donatella Pietrella, Andrea Astolfi, Serena Massari, Oriana Tabarrini, Giuseppe Manfroni, Maria Letizia Barreca and 3 more

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Fighting Antimicrobial Resistance: Insights on How theJournal of chemical information and modeling · 2023
    Article
  4. Review
  5. Inhibition ofAntibiotics (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Structural Modifications of the Quinolin-4-yloxy Core to Obtain NewInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tommaso FelicettiDepartment of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Gianmarco MangiaterraDepartment of Life and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy.
Rolando CannalireDepartment of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.ORCID https://orcid.org/0000-0003-0460-6731
Nicholas CedraroDepartment of Life and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy.
Donatella PietrellaDepartment of Pharmaceutical Sciences, Biochemical Sciences and Health Section, Università degli Studi di Perugia, Perugia, Italy.ORCID https://orcid.org/0000-0003-1572-4290
Andrea AstolfiDepartment of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Serena MassariDepartment of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.ORCID https://orcid.org/0000-0002-9992-6318
Oriana TabarriniDepartment of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.ORCID https://orcid.org/0000-0003-2693-5675
Giuseppe ManfroniDepartment of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.ORCID https://orcid.org/0000-0003-0207-3927
Maria Letizia BarrecaDepartment of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.ORCID https://orcid.org/0000-0003-3530-5042
Violetta CecchettiDepartment of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.ORCID https://orcid.org/0000-0001-8558-7004
Francesca BiavascoDepartment of Life and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy.ORCID https://orcid.org/0000-0002-8582-2227
Stefano SabatiniDepartment of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.ORCID https://orcid.org/0000-0003-0971-3536

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NorA is the most studied efflux pump of

Indexed as

Anti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsBacterial ProteinsMicrobial Sensitivity TestsMolecular StructureQuinolinesStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsBacterial ProteinsNorA protein, StaphylococcusquinolineQuinolinesantimicrobial resistanceAntimicrobial resistance breakersefflux pump inhibitorsNorAStaphylococcus aureus

Identifiers

PMID31992093
PMCPMC7034129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.