Evidence map›Paper›PMID 31991941›Full record

ArticleCells2020

Allergen-Induced C5a/C5aR1 Axis Activation in Pulmonary CD11b

Konstantina Antoniou, Fanny Ender, Tillman Vollbrandt, Yves Laumonnier, Franziska Rathmann, Chandrashekhar Pasare, Harinder Singh, Jörg Köhl

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. The innate immune brakes of the lung.Frontiers in immunology · 2023
    Review
  5. Review
  6. Review
  7. The Roles of Orphan G Protein-Coupled Receptors in Autoimmune Diseases.Clinical reviews in allergy & immunology · 2021
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Konstantina AntoniouInstitute for Systemic Inflammation Research, University of Lübeck, 23562 Lübeck, Germany.ORCID 0000-0001-8103-367X
Fanny EnderInstitute for Systemic Inflammation Research, University of Lübeck, 23562 Lübeck, Germany.
Tillman VollbrandtCell Analysis Core, University of Lübeck, 23562 Lübeck, Germany.
Yves LaumonnierInstitute for Systemic Inflammation Research, University of Lübeck, 23562 Lübeck, Germany.ORCID 0000-0001-9603-3269
Franziska RathmannInstitute for Systemic Inflammation Research, University of Lübeck, 23562 Lübeck, Germany.
Chandrashekhar PasareDivision of Immunobiology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0002-8142-2488
Harinder SinghDivision of Immunobiology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Jörg KöhlInstitute for Systemic Inflammation Research, University of Lübeck, 23562 Lübeck, Germany.ORCID 0000-0003-1121-3178
University of Lübeck · DECincinnati Children's Hospital Medical Center · USGerman Center for Lung Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activation of the C5/C5a/C5a receptor 1 (C5aR1) axis during allergen sensitization protects from maladaptive T cell activation. To explore the underlying regulatory mechanisms, we analyzed the impact of C5aR1 activation on pulmonary CD11b

Indexed as

Immune ToleranceAllergensAnimalsCD11b AntigenCD40 AntigensCD4-Positive T-LymphocytesCell DifferentiationCell ProliferationCoculture TechniquesComplement C5aDendritic CellsFemaleHistocompatibility Antigens Class IILungMiceMice, Inbred BALB CAllergensC5ar1 protein, mouseCcr7 protein, mouseCD11b AntigenCD40 AntigensComplement C5aHistocompatibility Antigens Class IIItgam protein, mouseReceptor, Anaphylatoxin C5aReceptors, CCR7allergic asthmaC5a receptorCD40complementconventional dendritic cellhouse-dust-mite

Identifiers

PMID31991941
PMCPMC7072238
OpenAlexW3001176496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.