ReviewAntibiotics (Basel, Switzerland)2020
Anti-Fungal Efficacy and Mechanisms of Flavonoids.
Review in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
150 citing papers in PubMed, 1 synthesis or guideline pooled it, 425 citations in OpenAlex.
- Efficacy of botanical antifungal and conventional antifungal in the treatment of oral candidiasis: a systematic review and meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Bioactive Constituents ofACS omega · 2026Article
- Flavonoids as Antimicrobial Pesticides: Mechanisms of Action, Formulation Strategies, and Perspectives for Pre- and Postharvest Disease Management.Plants (Basel, Switzerland) · 2026Review
- Enzyme-Assisted Ultrasonic Extraction of a Polysaccharide-Rich Extract fromMolecules (Basel, Switzerland) · 2026Article
- Integrated Chemical Profiling and Biological Assessment ofAntibiotics (Basel, Switzerland) · 2026Article
- UPLC-QTOF-MS/MS and Antifungal Activity of a Fraction Enriched in Saponins From Sarcomphalus joazeiro Against Candida spp.Biomedical chromatography : BMC · 2026Article
- Pilot Alkaline Extraction ofAntioxidants (Basel, Switzerland) · 2026Article
- Comparative Phytochemical Profiling and In Vitro Investigation of the Antioxidant and Antimicrobial Potential ofMolecules (Basel, Switzerland) · 2026Article
- ROS-Mediated Apoptosis-Like Death Induced by Genistein in Candida albicans.Current microbiology · 2026Article
- Sakuranetin, a Natural Flavonoid, Promising to Manage Grapevine Diseases.Molecules (Basel, Switzerland) · 2026Article
- Antioxidant and Antifungal Effects of Lavandula stoechas Aqueous Extract Against Aspergillus niger and Fusarium oxysporum as a Potential Natural Preservative and Crop Protection Agent in the Agrifood Sector.Chemistry & biodiversity · 2026Article
- Flavonoids as a Potential Antifungal Alternative AgainstJournal of fungi (Basel, Switzerland) · 2026Article
- Development of Bioactive Carboxymethyl Cellulose-Based Films via Dual Crosslinking with Citric Acid and X-Ray Irradiation.Foods (Basel, Switzerland) · 2026Article
- Detoxification of conifer antimicrobial defenses promotes entomopathogenic fungus infection of bark beetles.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mechanistic Insights into Flavonoids in Cosmetic Applications: Multifunctional Roles and Formulation Considerations.Clinical, cosmetic and investigational dermatology · 2026Review
- Characteristics ofFrontiers in microbiology · 2026Article
- Natural product based approaches to overcomeFrontiers in antibiotics · 2026Review
- A review of flavonoids at the crossroads of plant defense: integrating biotic and abiotic stress tolerance through AI- and CRISPR/Cas-guided metabolic reprogramming.Frontiers in plant science · 2026Review
- Nutritional Composition, Phenolic Profile, Antioxidant, and Antimicrobial Activity of Bilberry, Lingonberry, and Blueberry Cultivars.International journal of food science · 2026Article
- Isolation, Characterization, and Modes of Action of Antifungal Compounds from Rhizomes of Dryopteris nigropaleacea.Current microbiology · 2025Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The prevalence of fungal infections is growing at an alarming pace and the pathogenesis is still not clearly understood. Recurrence of these fungal diseases is often due to their evolutionary avoidance of antifungal resistance. The development of suitable novel antimicrobial agents for fungal diseases continues to be a major problem in the current clinical field. Hence, it is urgently necessary to develop surrogate agents that are more effective than conventional available drugs. Among the remarkable innovations from earlier investigations on natural-drugs, flavonoids are a group of plant-derived substances capable of promoting many valuable effects on humans. The identification of flavonoids with possible antifungal effects at small concentrations or in synergistic combinations could help to overcome this problem. A combination of flavonoids with available drugs is an excellent approach to reduce the side effects and toxicity. This review focuses on various naturally occurring flavonoids and their antifungal activities, modes of action, and synergetic use in combination with conventional drugs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.