Evidence map›Paper›PMID 31991867›Full record

ArticleToxins2020

Carbamoylated Nail Proteins as Assessed by Near-Infrared Analysis are Associated with Load of Uremic Toxins and Mortality in Hemodialysis Patients.

Sander De Bruyne, Jonas Himpe, Sigurd E Delanghe, Griet Glorieux, Wim Van Biesen, Marc L De Buyzere, Marijn M Speeckaert, Joris R Delanghe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. The Potential Use of Near- and Mid-Infrared Spectroscopy in Kidney Diseases.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sander De BruyneDepartment of Clinical Chemistry, Ghent University, Ghent 9000, Belgium.
Jonas HimpeDepartment of Clinical Chemistry, Ghent University, Ghent 9000, Belgium.
Sigurd E DelangheDepartment of Nephrology, Ghent University, Ghent 9000, Belgium.
Griet GlorieuxDepartment of Nephrology, Ghent University, Ghent 9000, Belgium.
Wim Van BiesenDepartment of Nephrology, Ghent University, Ghent 9000, Belgium.
Marc L De BuyzereDepartment of Cardiology, Heart Center, Ghent University Hospital, Ghent 9000, Belgium.
Marijn M SpeeckaertDepartment of Nephrology, Ghent University, Ghent 9000, Belgium.
Joris R DelangheDepartment of Clinical Chemistry, Ghent University, Ghent 9000, Belgium.
Ghent University Hospital · BE

Funding

M.M.S. is a Senior Clinical Researcher for the Research Foundation Flanders (FWO). FWO 1843719N
6 · The paper itself

Abstract

Carbamoylation is an important risk factor for accelerated atherogenesis and mortality in patients undergoing hemodialysis (HD). We intended to explore whether carbamoylation as assessed by near-infrared (NIR) analysis of nail proteins is associated with (a) serum concentrations of representative uremic toxins and (b) mortality in HD patients. A total of 53 healthy volunteers and 84 consecutive HD patients were enrolled in this cross-sectional cohort study. Standard laboratory methods were used to measure routine parameters, whereas levels of uremic toxins were determined using reversed-phase high-performance liquid chromatography (RP-HPLC). Spectra of distal fingernail clippings were obtained using an Avantes NIR spectrometer and processed using chemometric data analysis. The second derivative of the peak intensity at 1494 nm attributed to N-H amide bands from NH

Indexed as

Protein CarbamylationRenal DialysisRenal Insufficiency, ChronicAdultAgedFemaleHumansMaleNailsProportional Hazards ModelsProteinsSpectroscopy, Near-InfraredToxins, BiologicalUremiaProteinsToxins, Biologicalcarbamoylationhemodialysiskeratinsmortalitynailsnear-infrared spectroscopyuremiauremic toxins

Identifiers

PMID31991867
PMCPMC7076796
OpenAlexW3004049009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.