Evidence map›Paper›PMID 31991796›Full record

ArticleCells2020

Tumor Infiltrating Neutrophils Are Enriched in Basal-Type Urothelial Bladder Cancer.

Giulio Eugenio Mandelli, Francesco Missale, Debora Bresciani, Luisa Benerini Gatta, Patrizia Scapini, Elena Caveggion, Elisa Roca, Mattia Bugatti, Matilde Monti, Luca Cristinelli and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Loss ofBladder cancer (Amsterdam, Netherlands) · 2022
    Article
  13. TargetingCancers · 2021
    Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Giulio Eugenio MandelliDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25125 Brescia, Italy.
Francesco MissaleDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25125 Brescia, Italy.
Debora BrescianiDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25125 Brescia, Italy.
Luisa Benerini GattaDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25125 Brescia, Italy.
Patrizia ScapiniSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Elena CaveggionSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Elisa RocaDepartment of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25100 Brescia, Italy.
Mattia BugattiDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25125 Brescia, Italy.
Matilde MontiDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25125 Brescia, Italy.
Luca CristinelliDepartment of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25100 Brescia, Italy.
Sandra BelottiDepartment of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25100 Brescia, Italy.
Claudio SimeoneDepartment of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25100 Brescia, Italy.
Stefano CalzaUnit of Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, 25125 Brescia, Italy.
Laura MelocchiDepartment of Pathology, Fondazione Poliambulanza, 25100 Brescia, Italy.
William VermiDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25125 Brescia, Italy.
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Brescia · ITUniversity of Verona · ITFondazione Poliambulanza Istituto Ospedaliero · ITKarolinska Institutet · SEOspedale Policlinico San Martino · ITWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUrothelial bladder cancers (UBCs) are distinct in two main molecular subtypes, namely basal and luminal type. Subtypes are also diverse in term of immune contexture, providing a rationale for patient selection to immunotherapy.

methodsBy digital microscopy analysis of a muscle-invasive BC (MIBC) cohort, we explored the density and clinical significance of CD66b

resultsBasal type BC contained a significantly higher density of CD66b

conclusionsTAN are recruited in basal type MIBC by pro-inflammatory CKs. This finding establishes a groundwork for a better understanding of the UBC immunity and its relevance.

Indexed as

AgedAged, 80 and overCarcinoembryonic AntigenCD3 ComplexCell Line, TumorCell MovementCell SurvivalChemokine CXCL1Chemokine CXCL2Databases, GeneticFemaleGene SilencingHumansImmunohistochemistryInterleukin-8Kaplan-Meier EstimateCarcinoembryonic AntigenCD3 ComplexCEACAM3 protein, humanChemokine CXCL1Chemokine CXCL2CXCL1 protein, humanCXCL2 protein, humanInterleukin-8STAT3 protein, humanSTAT3 Transcription Factorbasalbladder cancerCD3CD66btumor-associated neutrophils

Identifiers

PMID31991796
PMCPMC7072276
OpenAlexW3001105182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.