ReviewCancers2020
A Comprehensive Review of Calcium Electroporation -A Novel Cancer Treatment Modality.
Review in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 130 citations in OpenAlex.
- Combination of irreversible and calcium electroporation to overcome heterogeneity-associated incomplete ablation in the pancreas.Scientific reports · 2026Article
- Endoscopic Management of Malignancy-Related Gastrointestinal Bleeding: A Comprehensive Narrative Review.Medical sciences (Basel, Switzerland) · 2026Review
- Local modifications in tissular conditions before PFA increases acute lesion size.Heart rhythm O2 · 2026Article
- Permeability of Phospholipid Membranes to Divalent Cations: The Effect of Pulsed Electric Field.Molecules (Basel, Switzerland) · 2026Article
- Large cap-polyposis of the sigmoid successfully treated with endoscopic electroporation.Endoscopy · 2025Article
- Establishing a Salvage Endoscopic Electroporation (SEE) Service for Colorectal Cancer: The King's Protocol for Clinical Implementation.Journal of clinical medicine · 2025Review
- Effects of ultra-fast nanosecond electric pulses on mitochondria transmembrane potential and oxidation.Scientific reports · 2025Article
- Pioneering Endoscopic Calcium-Electroporation in Gastric Cancer: A Case Series of an Emerging Therapeutic Approach.Diseases (Basel, Switzerland) · 2025Article
- Electrical Stimulation of Cells: Drivers, Technology, and Effects.Chemical reviews · 2025Review
- Reassessing lidocaine as an electroporation sensitizer in vitro.Scientific reports · 2025Article
- CaUltrasonics sonochemistry · 2025Article
- Palliative Luminal Treatment of Colorectal Cancer Using Endoscopic Calcium-Electroporation: First Case Series from United Kingdom.Journal of clinical medicine · 2025Article
- Investigation of the Bystander Effect on Cell Viability After Application of Combined Electroporation-Based Methods.International journal of molecular sciences · 2025Article
- Reversible electroporation for cancer therapy.The British journal of radiology · 2025Review
- Calcium electroporation induces stress response through upregulation of HSP27, HSP70, aspartate β-hydroxylase, and CD133 in human colon cancer cells.Biological research · 2025Article
- Advances in Pharmaceutical Science in Electrochemotherapy: A Tribute to Prof. Jolanta Saczko.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Numerical assessments of geometry, proximity and multi-electrode effects on electroporation in mitochondria and the endoplasmic reticulum to nanosecond electric pulses.Scientific reports · 2024Article
- Electrochemotherapy and Calcium Electroporation on Hepatocellular Carcinoma Cells: An In-Vitro Investigation.Cardiovascular and interventional radiology · 2024Article
- Delivery of extracellular vesicles loaded with immune checkpoint inhibitors for immunotherapeutic management of glioma.Materials today. Bio · 2024Article
- Interplay between Electric Field Strength and Number of Short-Duration Pulses for Efficient Gene Electrotransfer.Pharmaceuticals (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Calcium electroporation is a potential novel anti-cancer treatment where high calcium concentrations are introduced into cells by electroporation, a method where short, high voltage pulses induce transient permeabilisation of the plasma membrane allowing passage of molecules into the cytosol. Calcium is a tightly regulated, ubiquitous second messenger involved in many cellular processes including cell death. Electroporation increases calcium uptake leading to acute and severe ATP depletion associated with cancer cell death. This comprehensive review describes published data about calcium electroporation applied in vitro, in vivo, and clinically from the first publication in 2012. Calcium electroporation has been shown to be a safe and efficient anti-cancer treatment in clinical studies with cutaneous metastases and recurrent head and neck cancer. Normal cells have been shown to be less affected by calcium electroporation than cancer cells and this difference might be partly induced by differences in membrane repair, expression of calcium transporters, and cellular structural changes. Interestingly, both clinical data and preclinical studies have indicated a systemic immune response induced by calcium electroporation. New cancer treatments are needed, and calcium electroporation represents an inexpensive and efficient treatment with few side effects, that could potentially be used worldwide and for different tumor types.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.