Understanding the Evolutionary Ecology of host--pathogen Interactions Provides Insights into the Outcomes of Insect Pest Biocontrol.

The use of viral pathogens to control thepopulation size of pest insects has produced both successful and unsuccessful outcomes. Here, we investigate whether those biocontrol successes and failures can be explained by key ecological and evolutionary processes between hosts and pathogens. Specifically, we examine how heterogeneity inpathogen transmission, ecological and evolutionary tradeoffs, andpathogen diversity affect insect population density and thus successful control. Wefirst review theexisting literature and then use numerical simulations of mathematical models to further explore these processes. Our results show that thecontrol of insect densities using viruses depends strongly on theheterogeneity of virus transmission among insects. Overall, increased heterogeneity of transmission reduces theeffect of viruses on insect densities and increases thelong-term stability of insect populations. Lower equilibrium insect densities occur when transmission is heritable and when there is atradeoff between mean transmission and insect fecundity compared to when theheterogeneity of transmission arises from non-genetic sources. Thus, theheterogeneity of transmission is akey parameter that regulates thelong-term population dynamics of insects and their pathogens. Wealso show that both heterogeneity of transmission and life-history tradeoffs modulate characteristics of population dynamics such as thefrequency and intensity of ``boom--bust" population cycles. Furthermore, we show that because of life-history tradeoffs affecting thetransmission rate, theuse of multiple pathogen strains is more effective than theuse of asingle strain to control insect densities only when thepathogen strains differ considerably intheir transmission characteristics. By quantifying theeffects of ecology and evolution on population densities, we are able to offer recommendations to assess thelong-term effects of classical biocontrol.