Evidence map›Paper›PMID 31991700›Full record

ArticleCells2020

Urine microRNA Profiling Displays miR-125a Dysregulation in Children with Fragile X Syndrome.

Noora Putkonen, Asta Laiho, Doug Ethell, Juha Pursiheimo, Anna-Kaisa Anttonen, Juho Pitkonen, Adriana M Gentile, Yolanda de Diego-Otero, Maija L Castrén

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Noora PutkonenFaculty of Medicine, Physiology, University of Helsinki, FI-00014 Helsinki, Finland.
Asta LaihoTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, Tykistökatu 6A, FI-20520 Turku, Finland.
Doug EthellLeucadia Therapeutics Inc., Riverside, CA 92506, USA.
Juha PursiheimoThe Joint Clinical Biochemistry Laboratory of University of Turku, University Central Hospital and Wallac Oy, FI-20520 Turku, Finland.
Anna-Kaisa AnttonenDepartment of Clinical Genetics, University Hospital of Helsinki, 160, FI-00290 Helsinki, Finland.
Juho PitkonenFaculty of Medicine, Physiology, University of Helsinki, FI-00014 Helsinki, Finland.
Adriana M GentileInstitute of Biomedical Research of Malaga (IBIMA) and Mental Health Unit, Regional University Hospital of Malaga, University of Malaga, Research lab. Hospital Civil, Pab-6 sot. 29009 Malaga, Spain.
Yolanda de Diego-OteroInstitute of Biomedical Research of Malaga (IBIMA) and Mental Health Unit, Regional University Hospital of Malaga, University of Malaga, Research lab. Hospital Civil, Pab-6 sot. 29009 Malaga, Spain.
Maija L CastrénFaculty of Medicine, Physiology, University of Helsinki, FI-00014 Helsinki, Finland.
Instituto de Investigación Biomédica de Málaga · ESUniversity of Helsinki · FIÅbo Akademi University · FIUniversity of California, Riverside · USUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A triplet repeat expansion leading to transcriptional silencing of the

Indexed as

AdolescentBiomarkersChildChild, PreschoolFemaleFragile X SyndromeHigh-Throughput Nucleotide SequencingHumansMaleMicroRNAsMutationReceptors, Metabotropic GlutamateSignal TransductionBiomarkersMicroRNAsMIRN125 microRNA, humanReceptors, Metabotropic Glutamateautismdisease biomarkerfragile X syndromemiR-125aurine miRNA

Identifiers

PMID31991700
PMCPMC7072127
OpenAlexW3002565258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.