Evidence map›Paper›PMID 31991674›Full record

ArticleViruses2020

Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus.

Robert A Kozak, Lee W Goneau, Cedric DeLima, Olivia Varsaneux, AliReza Eshaghi, Erik Kristjanson, Romy Olsha, David Safronetz, Stephen Perusini, Christine Frantz and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Robert A KozakDivision of Microbiology, Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.
Lee W GoneauPublic Health Ontario, Toronto, ON M5G 1V2, Canada.
Cedric DeLimaPublic Health Ontario, Toronto, ON M5G 1V2, Canada.
Olivia VarsaneuxGovernment of Canada, Ottawa, ON K1Z 8R9, Canada.
AliReza EshaghiPublic Health Ontario, Toronto, ON M5G 1V2, Canada.
Erik KristjansonPublic Health Ontario, Toronto, ON M5G 1V2, Canada.
Romy OlshaPublic Health Ontario, Toronto, ON M5G 1V2, Canada.
David SafronetzSpecial Pathogens Program, National Microbiology Laboratory, Winnipeg, MB R3E 3R2, Canada.
Stephen PerusiniPublic Health Ontario, Toronto, ON M5G 1V2, Canada.
Christine FrantzPublic Health Ontario, Toronto, ON M5G 1V2, Canada.
Jonathan B GubbayDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Public Health Ontario · CAGovernment of Canada · CAHospital for Sick Children · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zika virus (ZIKV) is a mosquito-borne flavivirus associated with a febrile illness as well as severe complications, including microcephaly and Guillain-Barré Syndrome. Antibody cross-reactivity between flaviviruses has been documented, and in regions where ZIKV is circulating, dengue virus (DENV) is also endemic, leaving the potential that previous exposure to DENV could alter clinical features of ZIKV infection. To investigate this, we performed a retrospective case-control study in which we compared Canadian travellers who had been infected with ZIKV and had serological findings indicating previous DENV or other flavivirus exposure (

Indexed as

ViremiaAdultAntibodies, ViralCanadaCase-Control StudiesDengue VirusHumansMiddle AgedReal-Time Polymerase Chain ReactionRetrospective StudiesReverse Transcriptase Polymerase Chain ReactionSeverity of Illness IndexTravel-Related IllnessZika VirusZika Virus InfectionAntibodies, Viralantibodiesclinical diseasedengue virusviremiaZika virus

Identifiers

PMID31991674
PMCPMC7077307
OpenAlexW3001290276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.