Evidence map›Paper›PMID 31991664›Full record

ArticlePharmaceutics2020

Targeting Small Molecule Delivery to the Brain and Spinal Cord via Intranasal Administration of Rabies Virus Glycoprotein (RVG29)-Modified PLGA Nanoparticles.

Eugene P Chung, Jennifer D Cotter, Alesia V Prakapenka, Rebecca L Cook, Danielle M DiPerna, Rachael W Sirianni

Abstract read
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Nanotherapeutics for Alleviating Anesthesia-Associated Complications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eugene P ChungBarrow Brain Tumor Research Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Jennifer D CotterVivian L. Smith Department of Neurosurgery, McGovern Medical School, Houston, TX 77030, USA.
Alesia V PrakapenkaBarrow Brain Tumor Research Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Rebecca L CookBarrow Brain Tumor Research Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Danielle M DiPernaBarrow Brain Tumor Research Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Rachael W SirianniBarrow Brain Tumor Research Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA.

Funding

Intrathecal delivery of radiation sensitizing nanoparticles in pediatric neuro-oncologyR01HD099543 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SIRIANNI, RACHAEL W · 2019 to 2023
$3.5M
Exploiting sex-dependent brain injury response for nanoparticle therapeuticsR01NS116657 · NINDS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI SIRIANNI, RACHAEL W, STABENFELDT, SARAH E · 2021 to 2025
$2.5M
Targeting Leptomeningeal Metastasis in MedulloblastomaR01NS111292 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SIRIANNI, RACHAEL W · 2019 to 2024
$2.4M
Nanotherapeutics to alleviate neuroinflammation after TBIR21NS107985 · NINDS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI SIRIANNI, RACHAEL W, STABENFELDT, SARAH E · 2018 to 2019
$425k
Barrow Neurological Institute N.A.Ben and Catherine Ivy Foundation N.A.National Science Foundation DGE-1311230NICHD NIH HHS R01 HD099543NIH HHS R01NS111292NINDS NIH HHS R01 NS111292NINDS NIH HHS R01 NS116657NINDS NIH HHS R21 NS107985U.S. Department of Defense W81XWH-14-1-0311
6 · The paper itself

Abstract

Alternative routes of administration are one approach that could be used to bypass the blood-brain barrier (BBB) for effective drug delivery to the central nervous system (CNS). Here, we focused on intranasal delivery of polymer nanoparticles. We hypothesized that surface modification of poly(lactic-

Indexed as

brainintranasalnanoparticlerabies virus glycoproteinspinal cordtargeting

Identifiers

PMID31991664
PMCPMC7076461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.