ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2020
Frontal theta and beta oscillations during lower-limb movement in Parkinson's disease.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06984757 (Mid-frontal Delta/Theta and Cognitive Control), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mid-frontal Delta/Theta and Cognitive Control
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Characterization of EEG Data Revealing Relationships With Cognitive and Motor Symptoms in Parkinson's Disease: A Systematic Review.Frontiers in aging neuroscience · 2020Pooled it
- Effects of theta burst stimulation on the Parkinsonian gait disorder and cortical gait-network activity.Journal of Parkinson's disease · 2025Trial
- Frequency-Specific EEG burst dynamics in Parkinson's Disease and freezing of gait.Journal of neurology · 2026Article
- Behavioral changes preceded by subthalamic nucleus activity alterations in a progressive macaque model of Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Rewiring Recovery: Cognitive and Motor Gains Through Personalized Neurofeedback After Tumor Resection-A Case Series from Neurorehabilitation Practice.Applied psychophysiology and biofeedback · 2026Article
- Aberrant Beta-Band Network Alteration Preceding Freezing of Gait in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Task-specific dynamical entropy variations in EEG as a biomarker for Parkinson's disease progression.GeroScience · 2026Article
- EEG classification for neurological disorders using frequency band deciles.Scientific reports · 2025Article
- Assessing rhythm reproducibility during gait after internal rhythm-learning tasks: a pilot study in healthy adults and patients with Parkinson's disease.Journal of physical therapy science · 2025Article
- Amphetamine increases timing variability by degrading prefrontal temporal encoding.Neuropharmacology · 2025Article
- Advancing Gait Analysis: Integrating Multimodal Neuroimaging and Extended Reality Technologies.Bioengineering (Basel, Switzerland) · 2025Review
- Reduced Modulation of Theta and Beta Oscillations Mediates Empathy Impairment in Parkinson's Disease.Brain and behavior · 2025Article
- Cerebellar Oscillatory Patterns in Essential Tremor: Modulatory Effects of VIM-DBS.Cerebellum (London, England) · 2025Article
- Baseline-dependent network reactivity to visual input in children with autism spectrum disorder: a magnetoencephalography study.Frontiers in psychiatry · 2025Article
- EEG β oscillations in aberrant data perception under cognitive load modulation.Scientific reports · 2024Article
- Multi-Scale Feature and Multi-Channel Selection toward Parkinson's Disease Diagnosis with EEG.Sensors (Basel, Switzerland) · 2024Article
- Modulation of Cerebellar Oscillations with Subthalamic Stimulation in Patients with Parkinson's Disease.Journal of Parkinson's disease · 2024Article
- Executive function elevated by long term high-intensity physical activity and the regulation role of beta-band activity in human frontal region.Cognitive neurodynamics · 2023Article
- Evoked mid-frontal activity predicts cognitive dysfunction in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Parkinson Disease Recognition Using a Gamified Website: Machine Learning Development and Usability Study.JMIR formative research · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesPatients with Parkinson's disease (PD) have deficits in lower-limb functions such as gait, which involves both cognitive and motor dysfunction. In PD, theta and beta brain rhythms are associated with cognitive and motor functions, respectively. We tested the hypothesis that PD patients with lower-limb abnormalities would exhibit abnormal theta and beta rhythms in the mid-frontal cortical region during lower-limb action.
methodsThis study included thirty-nine participants; 13 PD patients with FOG (PDFOG+), 13 without FOG (PDFOG-), and 13 demographically-matched controls. We recorded scalp electroencephalograms (EEG) during a lower-limb pedaling motor task, which required intentional initiation and stopping of a motor movement.
resultsFOG scores were correlated with disease severity and cognition. PDFOG+ patients pedaled with reduced speed and decreased acceleration compared to PDFOG- patients and controls. PDFOG+ patients exhibited attenuated theta-band (4-8 Hz) power and increased beta-band (13-30 Hz) power at mid-frontal electrode Cz during pedaling. Frontal theta- and beta-band oscillations also correlated with motor and cognitive deficits.
conclusionFrontal theta and beta oscillations are predictors of lower-limb motor symptoms in PD and could be used to design neuromodulation for PD-related lower-limb abnormalities. SIGNIFICANCE: These data provide insight into mechanisms of lower-limb dysfunction in PD with FOG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.