Evidence map›Paper›PMID 31991282›Full record

ArticlePsychiatry research2020

Post-trauma anhedonia is associated with increased substance use in a recently-traumatized population.

Negar Fani, Jahnvi Jain, Lauren A Hudak, Barbara O Rothbaum, Kerry J Ressler, Vasiliki Michopoulos

Open access · greenAbstract read
In one paragraph

Article in Psychiatry research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Review
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  4. Trajectories of Anhedonia Symptoms after Traumatic Injury.European journal of trauma & dissociation = Revue europeenne du trauma et de la dissociation · 2024
    Article
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  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Negar FaniEmory University School of Medicine, Department of Psychiatry and Behavioral Sciences, USA. Electronic address: nfani@emory.edu.
Jahnvi JainEmory University School of Medicine, Department of Psychiatry and Behavioral Sciences, USA.
Lauren A HudakEmory University School of Medicine, Department of Emergency Medicine, USA.
Barbara O RothbaumEmory University School of Medicine, Department of Psychiatry and Behavioral Sciences, USA.
Kerry J ResslerEmory University School of Medicine, Department of Psychiatry and Behavioral Sciences, USA; McLean Hospital, Harvard Medical School, USA.
Vasiliki MichopoulosEmory University School of Medicine, Department of Psychiatry and Behavioral Sciences, USA; Yerkes National Primate Research Center, Atlanta, GA, USA.
Emory University · USEmory National Primate Research CenterHarvard University · US

Funding

Longitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8M
Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Cecile Delille Lahiri, Vasiliki Michopoulos · 2018 to 2026
$12.2M
Emory University BIRCWH ProgramK12HD085850 · NICHD · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, STERK, CLAIRE E · 2015 to 2023
$4.4M
2 of 2 Prospective Determination of Psychobiological Risk Factors for PTSDR01MH094757 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2012 to 2016
$2.3M
Emory R38 Research Training ProgramR38AI140299 · NIAID · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, ROUPHAEL, NADINE GEORGES · 2018 to 2021
$1.4M
Neural Mechanisms of Cognitive Control in Posttraumatic Stress DisorderK23MH101380 · NIMH · EMORY UNIVERSITY · PI FANI, NEGAR · 2014 to 2017
$601k
NIAID NIH HHS R38 AI140299NIA NIH HHS U54 AG062334NICHD NIH HHS K12 HD085850NIMH NIH HHS K23 MH101380NIMH NIH HHS R01 MH094757NIMH NIH HHS U01 MH110925
6 · The paper itself

Abstract

Recreational substance use (SU) can emerge or worsen in the aftermath of psychological trauma. Anhedonia is one reason for this problematic SU. Symptoms of posttraumatic stress disorder (PTSD) that represent anhedonia (post-trauma anhedonia; PTA) have been consistently linked to SU disorders. However, no prospective studies have examined whether changes in PTA over time are associated with problematic SU in recently-traumatized people, which was the goal of this study. 165 men and women were recruited as part of a prospective PTSD study in the emergency department of a Level 1 trauma center. Clinical assessments of PTSD and SU were administered at three and six months post-trauma. Compared to participants with minimal SU at six months post-trauma, high substance users at six months post-trauma showed significant increases in PTA during the three to six month time period. This relationship was significant even after accounting for variance associated with other factors, including PTSD symptoms such as re-experiencing and hyperarousal. Participants who demonstrated increases in SU during this time also showed significant increases in PTA, unlike those who demonstrated consistently minimal/no SU during this time. These findings indicate that PTA may be a mechanism through which SU problems emerge in recently-traumatized individuals.

Indexed as

AnhedoniaEmergency departmentPTSDSubstance useTrauma

Identifiers

PMID31991282
PMCPMC7544530
OpenAlexW2999259160

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.