Evidence map›Paper›PMID 31991042›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020

Targeting of intragraft reactive oxygen species by APP-103, a novel polymer product, mitigates ischemia/reperfusion injury and promotes the survival of renal transplants.

Koichiro Minami, Soochan Bae, Hirofumi Uehara, Chen Zhao, Dongwon Lee, Jasper Iske, Michael W Fanger, Jake Reder, Ian Morrison, Haruhito Azuma and 6 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Highly sensitive HActa pharmaceutica Sinica. B · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Quantitative increase in short-chain fatty acids, especially butyrate protects kidney from ischemia/reperfusion injury.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2022
    Article
  16. Endogenous memory T cells with donor-reactivity: early post-transplant mediators of acute graft injury in unsensitized recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2021
    Review
  17. Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 4 countries.

Koichiro MinamiDivision of Transplant Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Soochan BaeBeth Israel Deaconess Medical Center, Cardiovascular Institute, Boston, Massachusetts, USA.
Hirofumi UeharaDivision of Transplant Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Chen ZhaoDepartment of Physics, Institute for Soft Matter Synthesis and Metrology, Georgetown University, Washington, DC, USA.
Dongwon LeeDepartment of BIN Fusion Technology, Chonbuk National University, Jeonju, South Korea.
Jasper IskeDivision of Transplant Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Michael W FangerCeldara Medical, LLC, Lebanon, New Hampshire, USA.
Jake RederCeldara Medical, LLC, Lebanon, New Hampshire, USA.
Ian MorrisonOwen Corporation, LLC Georgetown, Washington, DC, USA.
Haruhito AzumaDepartment of Urology, Osaka Medical College, Takatsuki-city, Osaka, Japan.
Astrid WiensDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Edward Van KeurenDepartment of Physics, Institute for Soft Matter Synthesis and Metrology, Georgetown University, Washington, DC, USA.
Brandy HouserCeldara Medical, LLC, Lebanon, New Hampshire, USA.ORCID 0000-0003-1855-1401
Abdala ElKhalDivision of Transplant Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Peter M KangBeth Israel Deaconess Medical Center, Cardiovascular Institute, Boston, Massachusetts, USA.
Stefan G TulliusDivision of Transplant Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Brigham and Women's Hospital · USCeldara Medical (United States) · USBeth Israel Deaconess Medical Center · USGeorgetown University · USJeonbuk National University · KROsaka Medical and Pharmaceutical University · JP

Funding

Senescent cells drive mt-DNA accumulation and inflamm-agingR01AG064165 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI TULLIUS, STEFAN GUNTHER · 2020 to 2024
$2.6M
The microbiota and allograft rejection: novel investigations into the consequences of obesityU01AI132898 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ALEGRE, MARIA-LUISA, PERKINS, DAVID LINN · 2017 to 2021
$2.3M
Therapy of transplantation-induced oxidative injury using polymeric antioxidantsR44DK103389 · NIDDK · CELDARA MEDICAL, LLC · PI FANGER, MICHAEL W · 2014 to 2016
$1.7M
NIAID NIH HHS U01 AI132898NIA NIH HHS R01 AG064165NIDDK NIH HHS R44 DK103389NIDDK NIH HHS R44DK103389
6 · The paper itself

Abstract

Inflammatory responses associated with ischemia/reperfusion injury (IRI) play a central role in alloimmunity and transplant outcomes. A key event driving these inflammatory responses is the burst of reactive oxygen species (ROS), with hydrogen peroxide (H

Indexed as

Kidney TransplantationReperfusion InjuryAnimalsIschemiaPolymersRatsReactive Oxygen SpeciesPolymersReactive Oxygen Speciesfibrosisgraft survivalkidney (allograft) function/dysfunctionkidney transplantation: living donorkidney transplantation/nephrologytranslational research/science

Identifiers

PMID31991042
PMCPMC8609414
OpenAlexW3003459276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.