Evidence map›Paper›PMID 31991041›Full record

ArticleCancer science2020

Discovery of inner centromere protein-derived small peptides for cancer imaging and treatment targeting survivin.

Takeshi Fuchigami, Natsumi Ishikawa, Iori Nozaki, Yusuke Miyanari, Sakura Yoshida, Motohiro Yamauchi, Ayumi Soejima, Mamoru Haratake, Morio Nakayama

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. KNTC1 as a putative tumor oncogene in pancreatic cancer.Journal of cancer research and clinical oncology · 2023
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Takeshi FuchigamiDepartment of Hygienic Chemistry, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.ORCID https://orcid.org/0000-0001-8141-1212
Natsumi IshikawaDepartment of Hygienic Chemistry, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Iori NozakiDepartment of Hygienic Chemistry, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Yusuke MiyanariOkazaki Institute for Integrative Bioscience, Okazaki, Japan.
Sakura YoshidaDepartment of Hygienic Chemistry, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Motohiro YamauchiDepartment of Radiation Biology and Protection, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
Ayumi SoejimaDepartment of Hygienic Chemistry, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Mamoru HaratakeFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
Morio NakayamaDepartment of Hygienic Chemistry, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Nagasaki University · JPOkazaki Institute for Integrative Bioscience · JPSojo University · JP

Funding

Grant-in-Aid for JSPS Research Fellow 17J11488Grant-in-Aid for Scientific Research (C) 15K09895Grant-in-Aid for Young Scientists (B) 21791180
6 · The paper itself

Abstract

Survivin belongs to the inhibitor of apoptosis protein family, which is consistently overexpressed in most cancer cells but rarely expressed in normal adult tissues. Therefore, the detection and inhibition of survivin are regarded as attractive strategies for cancer-specific treatment. In this study, we designed and synthesized 7-19 residues of inner centromere protein (INCENP)-derived small peptides (INC peptides) as novel survivin-targeting agents. The INC peptides showed binding affinity for the human survivin protein (K

Indexed as

ApoptosisBreast NeoplasmsCaspasesCell Cycle ProteinsCell Line, TumorCell ProliferationChromosomal Proteins, Non-HistoneFemaleHumansInhibitor of Apoptosis ProteinsMolecular ImagingPeptidesSurvivinCaspasesCDCA8 protein, humanCell Cycle ProteinsChromosomal Proteins, Non-HistoneINCENP protein, humanInhibitor of Apoptosis ProteinsPeptidesSurvivinanticancerapoptosiscancer imagingpeptidesurvivin

Identifiers

PMID31991041
PMCPMC7156834
OpenAlexW3003843229

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.