ArticleThe New phytologist2020
Structural evolution drives diversification of the large LRR-RLK gene family.
Article in The New phytologist, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 112 citations in OpenAlex.
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- Pan-eukaryotic distribution and deep homology of plant small secreted peptides and their receptors.iScience · 2026Article
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- System drift in the evolution of plant meristem development.PLoS genetics · 2026Article
- Plant cell surface receptors.The Plant journal : for cell and molecular biology · 2026Review
- Genome-wide survey and expression analysis of peptides containing tyrosine sulfation (PSY) gene family in Cicer arietinum L.BMC genomics · 2026Article
- ERECTA genes and their ligands regulate shoot and inflorescence architecture in maize.Nature communications · 2026Article
- Phylogenomic and super-pangenome analyses unveil the genetic landscape of tomato evolution and domestication.Plant biotechnology journal · 2025Article
- Genome-wide identification and evolutionary analysis of disease resistance genes in Brassica carinata.The plant genome · 2025Article
- High-permeability cellulose nanocrystals mediate systemic zinc redistribution through nsLTP2-dependent immune potentiation in plants.Plant biotechnology journal · 2025Article
- ScWRKY2: a key regulator for smut resistance in sugarcane.Plant biotechnology journal · 2025Article
- Genome-wide investigation of peptides containing tyrosine sulfation (PSY) gene family: identification, evolutionary and expression analysis in soybean (Glycine max L.).BMC plant biology · 2025Article
- Genome-Wide Identification and Functional Prediction of LRR-RLK Family Genes in Foxtail Millet (International journal of molecular sciences · 2025Article
- The resistance awakens: Diversity at the DNA, RNA, and protein levels informs engineering of plant immune receptors from Arabidopsis to crops.The Plant cell · 2025Review
- Genome Identification, Expression Profile Analysis, and Abiotic Stress Response Mechanism of LonganInternational journal of molecular sciences · 2025Article
- Identification of the BBX gene family in blueberry at different chromosome ploidy levels and fruit development and response under stress.BMC genomics · 2025Article
- Genome-wide identification and expression analyses of theFrontiers in plant science · 2025Article
- Salicylic Acid-Induced Expression Profiles of LRR and LRR-RLK Candidate Genes ModulatePlants (Basel, Switzerland) · 2024Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
●Cells are continuously exposed to chemical signals that they must discriminate between and respond to appropriately. In embryophytes, the leucine-rich repeat receptor-like kinases (LRR-RLKs) are signal receptors critical in development and defense. LRR-RLKs have diversified to hundreds of genes in many plant genomes. Although intensively studied, a well-resolved LRR-RLK gene tree has remained elusive. ●To resolve the LRR-RLK gene tree, we developed an improved gene discovery method based on iterative hidden Markov model searching and phylogenetic inference. We used this method to infer complete gene trees for each of the LRR-RLK subclades and reconstructed the deepest nodes of the full gene family. ●We discovered that the LRR-RLK gene family is even larger than previously thought, and that protein domain gains and losses are prevalent. These structural modifications, some of which likely predate embryophyte diversification, led to misclassification of some LRR-RLK variants as members of other gene families. Our work corrects this misclassification. ●Our results reveal ongoing structural evolution generating novel LRR-RLK genes. These new genes are raw material for the diversification of signaling in development and defense. Our methods also enable phylogenetic reconstruction in any large gene family.
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