Evidence map›Paper›PMID 31990975›Full record

ArticleThe Journal of clinical endocrinology and metabolism2020

Associations of Innate and Adaptive Immune Cell Subsets With Incident Type 2 Diabetes Risk: The MESA Study.

Nels C Olson, Margaret F Doyle, Colleen M Sitlani, Ian H de Boer, Stephen S Rich, Sally A Huber, Alan L Landay, Russell P Tracy, Bruce M Psaty, Joseph A Delaney

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  4. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Nels C OlsonDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT.
Margaret F DoyleDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT.
Colleen M SitlaniDepartment of Medicine, University of Washington, Seattle, Washington.
Ian H de BoerDivision of Nephrology and Kidney Research Institute, Department of Medicine, University of Washington, Seattle, Washington.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
Sally A HuberDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT.
Alan L LandayDepartment of Internal Medicine, Rush University Medical Center, Chicago, Illinois.
Russell P TracyDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Kaiser Permanente Washington Health Research Institute, Seattle, Washington.
Joseph A DelaneyCardiovascular Health Research Unit, University of Washington, Seattle, Washington.
University of Vermont · USUniversity of Washington · USKaiser Permanente Washington Health Research Institute · USRush University Medical Center · USUniversity of Virginia · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5M
Phosphorus and Vitamin D Metabolism and Cardiovascular Outcomes: The multi-ethniR01HL096875 · NHLBI · UNIVERSITY OF WASHINGTON · PI DE BOER, IAN H, KESTENBAUM, BRYAN R · 2010 to 2019
$5.2M
Innate and adaptive immune-cell densities as risk factors for heart failureR01HL135625 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, TRACY, RUSSELL P · 2018 to 2021
$2.8M
T-cell subsets as CVD risk factors in CHS and MESAR01HL120854 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, TRACY, RUSSELL P · 2014 to 2017
$2.6M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
Immune Activation and Immunosenescence Biomarkers and Cardiovascular Disease RiskR00HL129045 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI OLSON, NELS C. · 2018 to 2020
$745k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS P01 HL136275NHLBI NIH HHS R00 HL129045NHLBI NIH HHS R01 HL096875NHLBI NIH HHS R01 HL120854NHLBI NIH HHS R01 HL135625
6 · The paper itself

Abstract

objectiveCell-mediated immunity is implicated in glucose homeostasis and insulin resistance. Whether the levels of innate and adaptive immune cells in peripheral blood are risk factors for incident type 2 diabetes (T2D) remains unknown. We hypothesized that the proportions of naive, memory, CD28-, Th17, and T regulatory CD4+ cells would be associated with incident T2D. In secondary analyses, we evaluated the relationships of 28 additional immune cell phenotypes with T2D.

designImmune cell phenotypes (n = 33) were measured by flow cytometry using cryopreserved cells collected from 1113 participants of the Multi-Ethnic Study of Atherosclerosis (MESA) at the baseline examination (2000-2002). Cox proportional hazards models were used to evaluate associations of immune cell phenotypes with incident T2D over a median follow-up of 9.1 years, adjusted for age, sex, race/ethnicity, educational status, and body mass index.

resultsIncident T2D was observed for 120 participants. None of the cell phenotypes included in the primary hypotheses were significantly associated with T2D (all P > 0.05). Among the secondary immune cells studied, a higher proportion of CD19+CD27+ B cells was associated with a reduced risk of T2D (hazard ratio: 0.72 (95% confidence interval: 0.56, 0.93), per 1-standard deviation (16%) increase). This association was no longer significant after correction for the multiple cell phenotypes tested (P > 0.0015).

conclusionsOur results suggest that the frequencies of several subsets of monocytes, innate lymphocytes, and CD4+ and CD8+ T cells in circulating blood are not related to the future onset of T2D. Higher levels of CD19+CD27+ B cells may be associated with decreased T2D risk.

Indexed as

Adaptive ImmunityAgedAged, 80 and overAtherosclerosisBiomarkersCase-Control StudiesCross-Sectional StudiesDiabetes Mellitus, Type 2EthnicityFemaleFollow-Up StudiesHumansImmunity, InnateMaleMiddle AgedMonocytesBiomarkersbiomarkersinflammationrisk factorsT cellstype 2 diabetes

Identifiers

PMID31990975
PMCPMC7049263
OpenAlexW3004262861

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.