ArticleJournal of experimental botany2020
NbCycB2 represses Nbwo activity via a negative feedback loop in tobacco trichome development.
Article in Journal of experimental botany, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Functional Characterisation of HAIRPLUS (NtHAP) Genes Involved in Trichome Development and Specialised Metabolism of Tobacco.Plant biotechnology journal · 2026Article
- ATML1-GIR1-TPL/TPR transcriptional repression module controls glucosinolates and giant cells inbioRxiv : the preprint server for biology · 2026Article
- The Genetic Wiring of Plant Trichomes: From Initiation to Fate Specification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Insight into the genetic network governing long-stalked glandular trichome development in Nicotiana tabacum.Planta · 2025Article
- Article
- ACL1-ROC4/5 complex reveals a common mechanism in rice response to brown planthopper infestation and drought.Nature communications · 2024Article
- Comparative transcriptome analysis reveals genes involved in trichome development and metabolism in tobacco.BMC plant biology · 2024Article
- A gradient of the HD-Zip regulator Woolly regulates multicellular trichome morphogenesis in tomato.The Plant cell · 2024Article
- Spatiotemporal formation of glands in plants is modulated by MYB-like transcription factors.Nature communications · 2024Article
- Formation mechanism of glandular trichomes involved in the synthesis and storage of terpenoids in lavender.BMC plant biology · 2023Article
- Transcription factors NtHD9 and NtHD12 control long glandular trichome formation via jasmonate signaling.Plant physiology · 2023Article
- Transcriptomic and functional analysis provides molecular insights into multicellular trichome development.Plant physiology · 2022Article
- NbJAZ3 is required for jasmonate-meditated glandular trichome development in Nicotiana benthamiana.Physiologia plantarum · 2022Article
- NtCycB2 negatively regulates tobacco glandular trichome formation, exudate accumulation, and aphid resistance.Plant molecular biology · 2022Article
- Cloning, characterization and functional analysis ofFrontiers in plant science · 2022Article
- Molecular Mechanisms of Plant Trichome Development.Frontiers in plant science · 2022Review
- Glandular trichomes: new focus on horticultural crops.Horticulture research · 2021Review
- The CBL-Interacting Protein Kinase NtCIPK23 Positively Regulates Seed Germination and Early Seedling Development in Tobacco (Plants (Basel, Switzerland) · 2021Article
- Mediation of JA signalling in glandular trichomes by the woolly/SlMYC1 regulatory module improves pest resistance in tomato.Plant biotechnology journal · 2021Article
- Comparative transcriptomics analysis revealing flower trichome development during flower development in two Lonicera japonica Thunb. cultivars using RNA-seq.BMC plant biology · 2020Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor Woolly (Wo) and its downstream gene CycB2 have been shown to regulate trichome development in tomato (Solanum lycopersicum). It has been demonstrated that only the gain-of-function allele of Slwo (SlWoV, the Slwo woolly motif mutant allele) can increase the trichome density; however, it remains unclear why the two alleles function differently in trichome development. In this study, we used Nicotiana benthamiana as a model and cloned the homologues of Slwo and SlCycB2 (named Nbwo and NbCycB2). We also constructed a Nbwo gain-of-function allele with the same mutation site as SlWoV (named NbWoV). We found that both Nbwo and NbWoV directly regulate NbCycB2 and their own expression by binding to the promoter of NbCycB2 and their own genomic sequences. As form of a feedback regulation, NbCycB2 negatively regulates trichome formation by repressing Nbwo activity at the protein level. We also found that mutations in the Nbwo woolly motif can prevent repression of NbWoV by NbCycB2, which results in a significant increase in the amount of active Nbwo proteins and in increases in trichome density and the number of branches. Our results reveal a novel reciprocal regulation mechanism between NbCycB2 and Nbwo during trichome formation in N. benthamiana.
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