ArticlePloS one2020
Recombination and gene loss occur simultaneously during bacterial horizontal gene transfer.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Genomic Characterization and Pathogenicity Island Analysis of 17 Mexican Isolates ofCurrent issues in molecular biology · 2026Article
- Investigating Additive and Replacing Horizontal Gene Transfers Using Phylogenies and Whole Genomes.Genome biology and evolution · 2024Article
- Native microbiome dominates over host factors in shaping the probiotic genetic evolution in the gut.NPJ biofilms and microbiomes · 2023Article
- Review
- Outer Membrane Vesicles TransmittingAntimicrobial agents and chemotherapy · 2023Article
- Biomanufacturing by In Vitro Biotransformation (ivBT) Using Purified Cascade Multi-enzymes.Advances in biochemical engineering/biotechnology · 2023Article
- Current Methods for Recombination Detection in Bacteria.International journal of molecular sciences · 2022Review
- Integrated Genomic and Metabolomic Analysis Illuminates Key Secreted Metabolites Produced by the Novel EndophyteMicroorganisms · 2022Article
- Outer Membrane Vesicles Derived fromInternational journal of molecular sciences · 2021Article
- Evolutionary history of Caulobacter toxin-antitoxin systems.Current microbiology · 2021Article
- Article
- Novel Caulobacter bacteriophages illustrate the diversity of the podovirus genus Rauchvirus.Archives of virology · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria can acquire new genes by incorporating environmental DNA into their genomes, yet genome sizes stay relatively constant. In nature, gene acquisition is a rare event so it is difficult to observe. However, the Caulobacter crescentus CB2A genome contains 114 insertions of genetic material from the closely-related NA1000 strain, providing a unique opportunity to analyze the horizontal transfer of genetic material. Analyses of these insertions led to a new model that involves preferential recombination at non-homologous regions that are flanked by regions of homology and does not involve any mutational processes. The net result is the replacement of segments of the recipient genome instead of the simple addition of genetic material during horizontal gene transfer. Analyses of the genomes of closely related strains of other bacterial and archaea genera, suggested that horizontal gene transfer occurs preferentially in non-homologous regions in these organisms as well. Thus, it appears to be a general phenomenon that prokaryotic horizontal gene transfer occurs preferentially at sites where the incoming DNA contains a non-homologous region that is flanked by regions of homology. Therefore, gene replacement is a common phenomenon during horizontal gene transfer.
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