Trial reportThe American journal of gastroenterology2020
Esophageal Hypervigilance and Visceral Anxiety Are Contributors to Symptom Severity Among Patients Evaluated With High-Resolution Esophageal Manometry.
Trial report in The American journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06883175 (Evolution of the Chicago Classification), which is not on this map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evolution of the Chicago Classification: Bridging Physiology and Mechanics
Who cites it
41 citing papers in PubMed, 72 citations in OpenAlex.
- Rhythmic contraction but arrhythmic distension of esophageal peristaltic reflex in patients with dysphagia.PloS one · 2022Trial
- Definition of Clinically Meaningful Thresholds for the Brief Esophageal Dysphagia Questionnaire and Eckardt Score: A Multicenter Psychometric Study.Neurogastroenterology and motility · 2026Article
- Ineffective Esophageal Motility and Its Predictors in Gastroesophageal Reflux Disease Patients with Pathologic Acid Exposure Time.Journal of neurogastroenterology and motility · 2026Article
- Laryngopharyngeal Symptoms and Laryngopharyngeal Reflux Disease: Interdisciplinary Considerations and Management.Neurogastroenterology and motility · 2026Review
- Early-Life and Psychosocial Factors in Adults with Symptoms Consistent with Retrograde Cricopharyngeus Dysfunction.Journal of clinical medicine · 2026Article
- Clinical characteristics and risk factors of refractory gastroesophageal reflux disease: A multicenter cross-sectional study.World journal of gastroenterology · 2025Observational
- The Acceptance, Commitment and COgnitive RemeDiation (ACCORD) Study: Can a Brief Online Cognitive Intervention Improve Outcomes in Patients With Esophageal Disease?Neurogastroenterology and motility · 2025Article
- Assessing Treatment Outcomes in Achalasia Using 4-Dimensional High-resolution Impedance Manometry.Journal of neurogastroenterology and motility · 2025Article
- Long-term Prognosis and Prognostic Factors in Ineffective Esophageal Motility.Journal of neurogastroenterology and motility · 2025Article
- Patient-Reported Outcome Measures in Benign Esophageal Disorders.The American journal of gastroenterology · 2025Review
- Validation of the Japanese version of the Esophageal Hypervigilance and Anxiety Scale for esophageal symptoms.Journal of gastroenterology · 2025Article
- Trauma and gastrointestinal symptoms in patients with gastroesophageal reflux disease: the role of emotional processing and mentalization.Gastroenterology and hepatology from bed to bench · 2025Article
- Real-life management of nonobstructive esophageal dysphagia: analysis of a prospective multicentric Portuguese cohort.Therapeutic advances in gastroenterology · 2025Article
- The synthesis of the psychosocial and the physiological aspects of chronic digestive disease is at a crossroads.Translational gastroenterology and hepatology · 2025Article
- Positive affect longitudinally buffers the negative effect of health anxiety on gastrointestinal symptoms.Applied psychology. Health and well-being · 2024Article
- Novel scale for evaluating the therapeutic efficacy of per-oral endoscopic myotomy in achalasia.Journal of gastroenterology · 2024Article
- Integrating psychological assessment in achalasia management: addressing mental health to enhance patient outcomes.European journal of translational myology · 2024Article
- Validation of the Laryngeal Cognitive-Affective Tool.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Article
- Correlations Between Anxiety and/or Depression Diagnoses and Dysphagia Severity.The Laryngoscope · 2024Article
- Optimal Assessment, Treatment, and Monitoring of Adults with Eosinophilic Esophagitis: Strategies to Improve Outcomes.ImmunoTargets and therapy · 2024Review
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 2 countries.
Funding
Abstract
objectivesSymptoms are inconsistently associated with esophageal motor findings on high-resolution manometry (HRM). We aimed to evaluate predictors of dysphagia severity, including esophageal hypervigilance and visceral anxiety, among patients evaluated with HRM.
methodsAdult patients undergoing HRM at 4 academic medical centers (United States and France) were prospectively evaluated. HRM was completed and analyzed per the Chicago Classification v3.0. Validated symptom scores, including the Brief Esophageal Dysphagia Questionnaire and Esophageal Hypervigilance and Anxiety Scale, were completed at the time of HRM.
resultsTwo hundred thirty-six patients, aged 18-85 (mean 53) years, 65% female, were included. Approximately 59 (25%) patients had a major motor disorder on HRM: 19 achalasia, 24 esophagogastric junction outflow obstruction, 12 absent contractility, and 4 jackhammer. Approximately 177 (75%) patients did not have a major motor disorder: 71 ineffective esophageal motility and 106 normal motility. Having a major motor disorder was a significant predictor of dysphagia severity (Radj = 0.049, P < 0.001), but the Esophageal Hypervigilance and Anxiety Scale score carried a predictive relationship of Brief Esophageal Dysphagia Questionnaire that was 2-fold higher than having a major motor disorder: Radj = 0.118 (P < 0.001). This finding remained when evaluated by the major motor disorder group. HRM metrics were nonsignificant. DISCUSSION: In a prospective, international multicenter study, we found that esophageal hypervigilance and visceral anxiety were the strongest predictors of dysphagia severity among patients evaluated with HRM. Thus, an assessment of esophageal hypervigilance and visceral anxiety is important to incorporate when evaluating symptom severity in clinical practice and research studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.