Evidence map›Paper›PMID 31990440›Full record

Trial reportPharmacology research & perspectives2020

Sultiame pharmacokinetic profile in plasma and erythrocytes after single oral doses: A pilot study in healthy volunteers.

Kim Dao, Paul Thoueille, Laurent A Decosterd, Thomas Mercier, Monia Guidi, Carine Bardinet, Sébastien Lebon, Eva Choong, Arnaud Castang, Catherine Guittet and 2 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pharmacology research & perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Kim DaoService of Clinical Pharmacology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-6033-3435
Paul ThoueilleService of Clinical Pharmacology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Laurent A DecosterdService of Clinical Pharmacology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Thomas MercierService of Clinical Pharmacology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Monia GuidiService of Clinical Pharmacology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Carine BardinetService of Clinical Pharmacology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Sébastien LebonUnit of Paediatric Neurology and Neurorehabilitation, Department Mother-Woman-Child, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Eva ChoongService of Clinical Pharmacology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Arnaud CastangAdvicenne Pharma SA, Nîmes, France.
Catherine GuittetAdvicenne Pharma SA, Nîmes, France.
Luc-André GranierAdvicenne Pharma SA, Nîmes, France.
Thierry BuclinService of Clinical Pharmacology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-0639-5536
University of Lausanne · CHAdvicenne Pharma (France) · FRHES-SO University of Applied Sciences and Arts Western Switzerland · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A pilot study was conducted aiming at specifying sultiame's pharmacokinetic profile, completed by in vitro assays evaluating the intraerythrocytic transfer of sultiame and by a pharmacokinetic model assessing its distribution. Single oral doses of sultiame (Ospolot

Indexed as

Administration, OralAdultArea Under CurveBenzenesulfonamidesErythrocytesHealthy VolunteersHumansMaleMetabolic Clearance RateOff-Label UsePilot ProjectsThiazinesUrineYoung AdultBenzenesulfonamidessulthiameThiazinesclearancehealthy volunteerspharmacokineticsultiamevolume of distribution

Identifiers

PMID31990440
PMCPMC6986439
OpenAlexW3003535682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.