Evidence map›Paper›PMID 31990187›Full record

ArticleAnalytical chemistry2020

Melting of Hemoglobin in Native Solutions as measured by IMS-MS.

Daniel W Woodall, Christopher J Brown, Shannon A Raab, Tarick J El-Baba, Arthur Laganowsky, David H Russell, David E Clemmer

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Thermal Remodeling of Human HDL Particles Reveals Diverse Subspecies.Journal of the American Society for Mass Spectrometry · 2024
    Article
  5. Resolving Hidden Solution Conformations of Hemoglobin Using IMS-IMS on a Cyclic Instrument.Journal of the American Society for Mass Spectrometry · 2023
    Article
  6. Dissecting the structural heterogeneity of proteins by native mass spectrometry.Protein science : a publication of the Protein Society · 2023
    Review
  7. Article
  8. Review
  9. Review
  10. Temperature Regulates Stability, Ligand Binding (MgJournal of the American Chemical Society · 2022
    Article
  11. Temperature-Controlled Electrospray Ionization: Recent Progress and Applications.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Native Mass Spectrometry of Iron-Sulfur Proteins.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Daniel W WoodallDepartment of Chemistry , Indiana University , Bloomington , Indiana 47405 , United States.
Christopher J BrownDepartment of Chemistry , Indiana University , Bloomington , Indiana 47405 , United States.
Shannon A RaabDepartment of Chemistry , Indiana University , Bloomington , Indiana 47405 , United States.
Tarick J El-BabaDepartment of Chemistry , Indiana University , Bloomington , Indiana 47405 , United States.
Arthur LaganowskyDepartment of Chemistry , Texas A & M University , College Station , Texas 77843 , United States.ORCID 0000-0001-5012-5547
David H RussellDepartment of Chemistry , Texas A & M University , College Station , Texas 77843 , United States.
David E ClemmerDepartment of Chemistry , Indiana University , Bloomington , Indiana 47405 , United States.ORCID 0000-0003-4039-1360
Indiana University Bloomington · USTexas A&M University · US

Funding

Waters Select Series Cyclic IMS for P41 Native MS Resource Application to Alzheimer's DiseaseP41GM128577 · NIGMS · OHIO STATE UNIVERSITY · PI WYSOCKI, VICKI H. · 2018 to 2022
$7.6M
Development of high resolution mobility measurements for structural biologyR01GM121751 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI CLEMMER, DAVID E., LAGANOWSKY, ARTHUR D · 2017 to 2020
$1.7M
NIGMS NIH HHS P41 GM128577NIGMS NIH HHS R01 GM121751
6 · The paper itself

Abstract

Thermally induced structural transitions of the quaternary structure of the hemoglobin tetramer (human) in aqueous solution (150 mM ammonium acetate) were investigated using a variable temperature electrospray ionization (vt-ESI) technique in combination with ion mobility spectrometry (IMS) and mass spectrometry (MS) measurements. At low solution temperatures (28 to ∼40 °C), a heterotetrameric (α

Indexed as

TemperatureHemoglobin AHumansIon Mobility SpectrometryMass SpectrometryProtein Structure, SecondarySolutionsHemoglobin ASolutions

Identifiers

PMID31990187
PMCPMC7480357
OpenAlexW3003486906

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.