ArticleeLife2020
TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury.
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In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 76 citations in OpenAlex.
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- Personalized Environment and Genes Study (PEGS) Dataset-a resource for genomic, exposomic, and geospatial data.Scientific data · 2026Article
- Examining the Interaction between Allergic Asthma and Air Pollution: a Potential Role for Trained Immunity.Current allergy and asthma reports · 2025Review
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- Integrative transcriptomic analysis reveals cross-species conserved core genes and pathways in alveolar macrophages during ALI/ARDS.BMC pulmonary medicine · 2025Article
- Evaluating the role of alveolar macrophages in tolerance to ozone.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Brucellosis novel multi-epitope vaccine design based on in silico analysis focusing on Brucella abortus.BMC immunology · 2025Article
- TLR5 Signaling Causes Dendritic Cell Dysfunction and Orchestrates Failure of Immune Checkpoint Therapy against Ovarian Cancer.Cancer immunology research · 2025Article
- New Exploration of Therapeutic Targets for Radiation Pneumonitis: Comparative Analysis of Molecular Pathways in Radiation-Induced and LPS-Induced Pneumonitis.International journal of medical sciences · 2025Review
- Cellular andThe journal of physical chemistry. B · 2024Article
- Sensing of an HIV-1-Derived Single-Stranded RNA-Oligonucleotide Induces Arginase 1-Mediated Tolerance.Cells · 2024Article
- JAK1/2 Regulates Synergy Between Interferon Gamma and Lipopolysaccharides in Microglia.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024Article
- Mesenchymal stem cells preconditioned with a TLR5 agonist enhanced immunoregulatory effect through M2 macrophage polarization in a murine graft-versus-host disease model.International journal of medical sciences · 2024Article
- Roles of airway and intestinal epithelia in responding to pathogens and maintaining tissue homeostasis.Frontiers in cellular and infection microbiology · 2024Review
- Toll-like receptor 4 in pancreatic damage and immune infiltration in acute pancreatitis.Frontiers in immunology · 2024Review
- Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics.Acta pharmacologica Sinica · 2023Review
- Infusible Extracellular Matrix Biomaterial Promotes Vascular Integrity and Modulates the Inflammatory Response in Acute Traumatic Brain Injury.Advanced healthcare materials · 2023Article
- Immunomodulatory contribution of mast cells to the regenerative biomaterial microenvironment.NPJ Regenerative medicine · 2023Article
- Interaction of TiOEnvironmental science. Nano · 2023Article
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 3 countries.
Salik Hussain *National Institute of Environmental Health Sciences, Research Triangle Park, United States.
Collin G Johnson *National Institute of Environmental Health Sciences, Research Triangle Park, United States.
Joseph Sciurba *National Institute of Environmental Health Sciences, Research Triangle Park, United States.
Xianglin MengNational Institute of Environmental Health Sciences, Research Triangle Park, United States.
Vandy P StoberNational Institute of Environmental Health Sciences, Research Triangle Park, United States.
Caini LiuLerner Research Institute, Cleveland Clinic Foundation, Cleveland, United States.
Jaime M Cyphert-DalyNational Institute of Environmental Health Sciences, Research Triangle Park, United States.
Katarzyna BulekLerner Research Institute, Cleveland Clinic Foundation, Cleveland, United States.ORCID 0000-0001-8064-7047
Wen QianLerner Research Institute, Cleveland Clinic Foundation, Cleveland, United States.
Alma SolisNational Institute of Environmental Health Sciences, Research Triangle Park, United States.
Yosuke SakamachiNational Institute of Environmental Health Sciences, Research Triangle Park, United States.
Carol S TrempusNational Institute of Environmental Health Sciences, Research Triangle Park, United States.
Jim J AloorNational Institute of Environmental Health Sciences, Research Triangle Park, United States.
Kym M GowdyNational Institute of Environmental Health Sciences, Research Triangle Park, United States.
W Michael FosterDuke University Medical Center, Durham, United States.
John W HollingsworthDuke University Medical Center, Durham, United States.
Robert M TigheDuke University Medical Center, Durham, United States.
Xiaoxia LiLerner Research Institute, Cleveland Clinic Foundation, Cleveland, United States.ORCID 0000-0002-4872-9525
Michael B FesslerNational Institute of Environmental Health Sciences, Research Triangle Park, United States.
Stavros GarantziotisNational Institute of Environmental Health Sciences, Research Triangle Park, United States.ORCID 0000-0003-4007-375X
Triangle · USCleveland Clinic · USDuke Medical Center · USEast Carolina University · USBaylor College of Medicine · USHarbin Medical University · CNJagiellonian University · PLNorth Carolina State University · USWest Virginia University · US
Funding
Cell Signaling of Host DefenseZIAES102005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI FESSLER, MICHAEL B · 2009 to 2025
$41.7MMolecular Genetics Support to Identify Gene/Environment Interactions in DiseaseZICES102546 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI GERRISH, KEVIN · 2009 to 2025
$30.5MThe Role of Hyaluronan And Inter-Alpha-Trypsin Inhibitor in Tissue InjuryZIAES102605 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI GARANTZIOTIS, STAVROS · 2009 to 2025
$22.6MCell Signaling of Host DefenseZ01ES102005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI FESSLER, MICHAEL B · 2006 to 2008
$3.3MCXCL10/CXCR3 regulation of ozone-induced epithelial permeabilityR01ES027574 · NIEHS · DUKE UNIVERSITY · PI TIGHE, ROBERT MATTHEW · 2018 to 2022
$3.1MThe Role of Hyaluronan And Inter-Alpha-Trypsin Inhibitor in Tissue InjuryZ01ES102605 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI GARANTZIOTIS, STAVROS · 2008 to 2008
$621kIntramural NIH HHS Z01 ES102005Intramural NIH HHS Z01 ES102605NIEHS NIH HHS R01 ES027574NIEHS NIH HHS Z01ES102005NIEHS NIH HHS Z01ES102605
Abstract
Lung disease causes significant morbidity and mortality, and is exacerbated by environmental injury, for example through lipopolysaccharide (LPS) or ozone (O
Indexed as
Lung InjuryMyeloid Differentiation Factor 88Signal TransductionToll-Like Receptor 4Toll-Like Receptor 5AnimalsCells, CulturedHumansInflammationLungMacrophagesMiceMice, Inbred C57BLMice, KnockoutPolymorphism, Single NucleotideMYD88 protein, humanMyd88 protein, mouseMyeloid Differentiation Factor 88TLR4 protein, humanTlr4 protein, mouseTLR5 protein, humanTlr5 protein, mouseToll-Like Receptor 4Toll-Like Receptor 5humanhuman biologyimmunologyinflammationinnate immune receptorsmedicinemouseTLR4TLR5
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.