Evidence map›Paper›PMID 31989862›Full record

ArticleMedical decision making : an international journal of the Society for Medical Decision Making2020

A Multidimensional Array Representation of State-Transition Model Dynamics.

Eline M Krijkamp, Fernando Alarid-Escudero, Eva A Enns, Petros Pechlivanoglou, M G Myriam Hunink, Alan Yang, Hawre J Jalal

Abstract readComparative Study
In one paragraph

Article in Medical decision making : an international journal of the Society for Medical Decision Making, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. A Tutorial on Discrete Event Simulation Models Using a Cost-Effectiveness Analysis Example in R.Medical decision making : an international journal of the Society for Medical Decision Making · 2026
    Article
  2. Cost-Effectiveness of First-Line Immunochemotherapy VersusCurrent oncology (Toronto, Ont.) · 2026
    Article
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  8. A Tutorial on Time-Dependent Cohort State-Transition Models in R Using a Cost-Effectiveness Analysis Example.Medical decision making : an international journal of the Society for Medical Decision Making · 2023
    Article
  9. CDX2 Biomarker Testing and Adjuvant Therapy for Stage II Colon Cancer: An Exploratory Cost-Effectiveness Analysis.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2022
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eline M KrijkampDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-3970-2205
Fernando Alarid-EscuderoDrug Policy Program, Center for Research and Teaching in Economics, (CIDE)-CONACyT, Aguascalientes, Ags., Mexico.ORCID 0000-0001-5076-1172
Eva A EnnsDivision of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Petros PechlivanoglouChild Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.
M G Myriam HuninkDepartments of Epidemiology and Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Alan YangChild Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0002-0344-6812
Hawre J JalalGraduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-8224-6834

Funding

Institutional Career Development CoreKL2TR001856 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, KRISTIN N, RUBIO, DORIS M · 2016 to 2025
$13.8M
Comparative Modeling of Colorectal Cancer: Informing Health Policies and Prioritizing Future ResearchU01CA199335 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KUNTZ, KAREN M, LANSDORP-VOGELAAR, IRIS · 2015 to 2019
$5.5M
Mathematical modeling and analysis of HIV care trajectories and retention in care challengesK25AI118476 · NIAID · UNIVERSITY OF MINNESOTA · PI ENNS, EVA A · 2015 to 2019
$649k
NCATS NIH HHS KL2 TR001856NCI NIH HHS U01 CA199335NIAID NIH HHS K25 AI118476
6 · The paper itself

Abstract

Cost-effectiveness analyses often rely on cohort state-transition models (cSTMs). The cohort trace is the primary outcome of cSTMs, which captures the proportion of the cohort in each health state over time (state occupancy). However, the cohort trace is an aggregated measure that does not capture information about the specific transitions among health states (transition dynamics). In practice, these transition dynamics are crucial in many applications, such as incorporating transition rewards or computing various epidemiological outcomes that could be used for model calibration and validation (e.g., disease incidence and lifetime risk). In this article, we propose an alternative approach to compute and store cSTMs outcomes that capture both state occupancy and transition dynamics. This approach produces a multidimensional array from which both the state occupancy and the transition dynamics can be recovered. We highlight the advantages of the multidimensional array over the traditional cohort trace and provide potential applications of the proposed approach with an example coded in R to facilitate the implementation of our method.

Indexed as

Cohort StudiesDecision Support TechniquesComputer SimulationCost-Benefit AnalysisEpidemiologic MethodsHumansModels, StatisticalSoftwarecost-effectiveness analysisdecision modelinghealth economicsmatricesmultidimensional arraysR projectstate-transition modelstensorstransition dynamicstransition rewards

Identifiers

PMID31989862
PMCPMC7065927

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.