Evidence map›Paper›PMID 31989826›Full record

ArticleJournal of natural products2020

Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabologenomic Approach.

Simon Sieber, Simone M Grendelmeier, Lonnie A Harris, Douglas A Mitchell, Karl Gademann

Open access · greenAbstract read
In one paragraph

Article in Journal of natural products, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
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  5. Review
  6. A cohesiveWater research X · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Catch-enrich-release approach for amine-containing natural products.Chemical communications (Cambridge, England) · 2022
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. First Report onToxins · 2021
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Simon SieberDepartment of Chemistry , University of Zurich , Winterthurerstrasse 190 , Zurich , CH 8057 , Switzerland.
Simone M GrendelmeierDepartment of Chemistry , University of Zurich , Winterthurerstrasse 190 , Zurich , CH 8057 , Switzerland.
Lonnie A HarrisDepartment of Chemistry , University of Illinois at Urbana-Champaign , 600 South Mathews Avenue , Urbana , Illinois 61801 , United States.
Douglas A MitchellDepartment of Chemistry , University of Illinois at Urbana-Champaign , 600 South Mathews Avenue , Urbana , Illinois 61801 , United States.ORCID 0000-0002-9564-0953
Karl GademannDepartment of Chemistry , University of Zurich , Winterthurerstrasse 190 , Zurich , CH 8057 , Switzerland.ORCID 0000-0003-3053-0689
University of Zurich · CHUniversity of Illinois Urbana-Champaign · US

Funding

Genomics-Accelerated Natural Product DiscoveryR01GM123998 · NIGMS · VANDERBILT UNIVERSITY · PI MITCHELL, DOUGLAS ALAN · 2017 to 2024
$2.6M
NIGMS NIH HHS R01 GM123998
6 · The paper itself

Abstract

The toxicity of the cyanobacterium

Indexed as

ChymotrypsinCyanobacteriaDepsipeptidesGenomicsMicrocystinsMicrocystisMolecular StructureMultigene FamilyProtease InhibitorsTandem Mass SpectrometryChymotrypsinDepsipeptidesMicrocystinsProtease Inhibitors

Identifiers

PMID31989826
PMCPMC7050427
OpenAlexW3003751929

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.