Evidence map›Paper›PMID 31989797›Full record

ArticleMolecular genetics & genomic medicine2020

Survey of Ehlers-Danlos Patients' ophthalmic surgery experiences.

Anita Louie, Catherine Meyerle, Clair Francomano, Divya Srikumaran, Farhan Merali, Jefferson J Doyle, Kraig Bower, Lara Bloom, Michael V Boland, Nicholas Mahoney and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics & genomic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Ophthalmic Implications of Ehlers-Danlos Syndrome.Clinical ophthalmology (Auckland, N.Z.) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Hypermobile Ehlers-Danlos syndromes: Complex phenotypes, challenging diagnoses, and poorly understood causes.Developmental dynamics : an official publication of the American Association of Anatomists · 2021
    Review
  8. Survey of Ehlers-Danlos Patients' ophthalmic surgery experiences.Molecular genetics & genomic medicine · 2020
    Article
  9. Recurrent Neural Networks to Automatically Identify Rare Disease Epidemiologic Studies from PubMed.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Anita LouieJohns Hopkins University, Baltimore, MD, USA.
Catherine MeyerleWilmer Eye Institute of Johns Hopkins Hospital, Baltimore, MD, USA.
Clair FrancomanoHarvey Institute for Medical Genetics of Greater Baltimore Medical Center, Baltimore, MD, USA.
Divya SrikumaranWilmer Eye Institute of Johns Hopkins Hospital, Baltimore, MD, USA.
Farhan MeraliWilmer Eye Institute of Johns Hopkins Hospital, Baltimore, MD, USA.
Jefferson J DoyleWilmer Eye Institute of Johns Hopkins Hospital, Baltimore, MD, USA.
Kraig BowerWilmer Eye Institute of Johns Hopkins Hospital, Baltimore, MD, USA.
Lara BloomEhlers Danlos Society, London, UK.
Michael V BolandWilmer Eye Institute of Johns Hopkins Hospital, Baltimore, MD, USA.
Nicholas MahoneyWilmer Eye Institute of Johns Hopkins Hospital, Baltimore, MD, USA.
Yassine DaoudWilmer Eye Institute of Johns Hopkins Hospital, Baltimore, MD, USA.
Eric L SingmanWilmer Eye Institute of Johns Hopkins Hospital, Baltimore, MD, USA.ORCID 0000-0003-0327-4675
Johns Hopkins Hospital · USGreater Baltimore Medical Center · USJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEhlers-Danlos Syndrome (EDS) is a rare disease affecting approximately 1 in 5,000 people. Although ophthalmic conditions associated with EDS have been described, little data exist concerning ophthalmic surgical outcomes experienced by EDS patients.

methodsPatients with EDS were surveyed via the EDS Society and asked about their ophthalmic surgical experiences including procedure, complications, and the timing with respect to receiving the EDS diagnosis. Complications were confirmed as such by subspecialists.

resultsOf 579 respondents, 467 reported confirmed EDS, and 112 of those had an ophthalmic procedure, including refractive surgery, cataract/lens surgery, retinal surgery, strabismus surgery, oculoplastic surgery, corneal surgery, and laser surgery for glaucoma. The rate of confirmed complications was: 23%-refractive, 33%-lens/cataract, 33%-retina, 59%-strabismus, 23%- oculoplastics, 0%-cornea, and 25%-glaucoma laser. In addition, 76% of patients underwent surgery prior to the EDS diagnosis.

conclusionsPatients with EDS may have elevated risk of postoperative ophthalmic surgical complications. It would seem reasonable to systemically and prospectively explore how patients with EDS respond to ophthalmic surgery. Furthermore, it would seem circumspect to ask surgical candidates patients about whether they carry a diagnosis of EDS or have signs and symptoms of EDS prior to surgery.

Indexed as

Patient Reported Outcome MeasuresEhlers-Danlos SyndromeHumansOphthalmologic Surgical ProceduresPatient SatisfactionPostoperative ComplicationscomplicationEhlers-Danloseyeophthalmologysurgery

Identifiers

PMID31989797
PMCPMC7196452
OpenAlexW3003553733

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.