Evidence map›Paper›PMID 31989589›Full record

ArticleClinical and experimental immunology2020

Low-dose IL-2 induces CD56

S L McQuaid, S T Loughran, P A Power, P Maguire, A Szczygiel, P A Johnson

Open access · bronzeAbstract read
In one paragraph

Article in Clinical and experimental immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Unconventional functions of natural killer cells in homeostasis and disease.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  3. Taming immune responses to AAV gene therapy by programmed in vivo Treg expansion.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  4. Review
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  6. Review
  7. Article
  8. Review
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  11. Sequential immunotherapy: towards cures for autoimmunity.Nature reviews. Drug discovery · 2024
    Review
  12. Review
  13. Natural killer cells in the central nervous system.Cell communication and signaling : CCS · 2023
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Targeting natural killer cells to enhance vaccine responses.Trends in pharmacological sciences · 2021
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

S L McQuaidViral Immunology Laboratory, School of Nursing, Psychotherapy and Community Health, Dublin City University, Dublin, Ireland.
S T Loughran *Viral Immunology Laboratory, School of Nursing, Psychotherapy and Community Health, Dublin City University, Dublin, Ireland.
P A Power *Viral Immunology Laboratory, School of Nursing, Psychotherapy and Community Health, Dublin City University, Dublin, Ireland.
P MaguireViral Immunology Laboratory, School of Nursing, Psychotherapy and Community Health, Dublin City University, Dublin, Ireland.
A SzczygielViral Immunology Laboratory, School of Nursing, Psychotherapy and Community Health, Dublin City University, Dublin, Ireland.
P A JohnsonViral Immunology Laboratory, School of Nursing, Psychotherapy and Community Health, Dublin City University, Dublin, Ireland.ORCID 0000-0002-2891-7940
Dublin City University · IETechnological University Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-dose interleukin (IL)-2 has shown clinical benefits in patients with autoimmune and inflammatory diseases. Both regulatory T cells (T

Indexed as

Autoimmune DiseasesCD56 AntigenHumansInterleukin-2Killer Cells, NaturalNatural Cytotoxicity Triggering Receptor 1Natural Cytotoxicity Triggering Receptor 2T-Lymphocytes, RegulatoryCD56 AntigenIL2 protein, humanInterleukin-2Natural Cytotoxicity Triggering Receptor 1Natural Cytotoxicity Triggering Receptor 2NCAM1 protein, humanNCR1 protein, humanNCR2 protein, humanautoimmunityCD56bright NKlow-dose IL-2NK cellsNKp44regulatory T cells

Identifiers

PMID31989589
PMCPMC7232012
OpenAlexW3003343921

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.