Evidence map›Paper›PMID 31989473›Full record

Observational studyCanadian journal of anaesthesia = Journal canadien d'anesthesie2020

Association between perioperative normal saline and delayed graft function in deceased-donor kidney transplantation: a retrospective observational study.

Nicolas Nesseler, Alexandre Rached, James T Ross, Yoann Launey, Cécile Vigneau, Karim Bensalah, Hélène Beloeil, Yannick Mallédant, Ronan Garlantezec, Philippe Seguin

Open access · bronzeAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Nicolas NesselerDepartment of Anesthesia and Critical Care, Pontchaillou, University Hospital of Rennes, Rennes, France. nicolas.nesseler@chu-rennes.fr.
Alexandre RachedDepartment of Anesthesia and Critical Care, Pontchaillou, University Hospital of Rennes, Rennes, France.
James T RossDepartment of Surgery, University of California, San Francisco, CA, USA.
Yoann LauneyDepartment of Anesthesia and Critical Care, Pontchaillou, University Hospital of Rennes, Rennes, France.
Cécile VigneauDepartment of Nephrology, Pontchaillou, University Hospital of Rennes, Rennes, France.
Karim BensalahDepartment of Urology, Pontchaillou, University Hospital of Rennes, Rennes, France.
Hélène BeloeilDepartment of Anesthesia and Critical Care, Pontchaillou, University Hospital of Rennes, Rennes, France.
Yannick MallédantDepartment of Anesthesia and Critical Care, Pontchaillou, University Hospital of Rennes, Rennes, France.
Ronan GarlantezecUniv Rennes, CHU de Rennes, Irset (Institut de recherche en santé, environnement et travail), Rennes, France.
Philippe SeguinDepartment of Anesthesia and Critical Care, Pontchaillou, University Hospital of Rennes, Rennes, France.
Hôpital Pontchaillou · FRInserm · FRInstitut de Recherche en Santé, Environnement et Travail · FRUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIsotonic 0.9% sodium chloride (normal saline; NS) solution use is common, but its high chloride content has been shown to contribute to acid-base disturbances and acute kidney injury (AKI). As kidney transplant recipients are at high risk of postoperative AKI and renal replacement therapy, we aimed to evaluate the impact of perioperative NS administration on graft function after kidney transplantation.

methodsAll adult patients undergoing deceased-donor kidney transplantation between January 2010 and December 2014 at the Rennes University Hospital were included. Logistic regression models were constructed to evaluate the association of hyperchloremia and hyperchloremic acidosis on delayed graft function (DGF), defined as the need for renal replacement therapy within the first week after transplantation.

resultsThree hundred and fifty-nine patients were included, 20% developed DGF. The mean (standard deviation) volume of NS infused in the operating room and in the standard postoperative intensive care unit stay was 4,832 (2,242) mL. In the first 24 postoperative hours, 11% of patients developed hyperchloremia and 11% developed hyperchloremic acidosis. These outcomes were not associated with significantly higher total volumes of NS administration or with DGF. In contrast, multivariable analysis showed that cold ischemia time, donor terminal creatinine, and perioperative NS volume were all independent predictors of DGF.

conclusionPerioperative NS infusion volume was associated with DGF in deceased-donor kidney transplant recipients. Conversely, postoperative hyperchloremia and hyperchloremic acidosis were not associated with an increased risk of DGF, suggesting other mechanisms than a chloride effect.

Indexed as

Kidney TransplantationDelayed Graft FunctionGraft SurvivalHumansRetrospective StudiesRisk FactorsSaline SolutionTissue DonorsSaline Solution

Identifiers

PMID31989473
OpenAlexW3001673503

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.