Evidence map›Paper›PMID 31989470›Full record

ArticleNeurochemical research2020

Thiamine Deficiency Modulates p38

Rita de Cássia Noronha Medeiros, Juliana Oliveira Moraes, Samara Dias Cardoso Rodrigues, Leidiano Martins Pereira, Helen Quézia da Silva Aguiar, Clarissa Amorim Silva de Cordova, Alberto Yim Júnior, Fabiano Mendes de Cordova

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rita de Cássia Noronha MedeirosPrograma de Pós-Graduação em Sanidade Animal e Saúde Pública nos Trópicos, Universidade Federal do Tocantins, BR-153, km 112, Araguaína, TO, 77804-970, Brazil.
Juliana Oliveira MoraesPrograma de Pós-Graduação em Sanidade Animal e Saúde Pública nos Trópicos, Universidade Federal do Tocantins, BR-153, km 112, Araguaína, TO, 77804-970, Brazil.
Samara Dias Cardoso RodriguesCurso de Medicina Veterinária, Universidade Federal do Tocantins, BR-153, km 112, Araguaína, TO, 77804-970, Brazil.
Leidiano Martins PereiraCurso de Medicina Veterinária, Universidade Federal do Tocantins, BR-153, km 112, Araguaína, TO, 77804-970, Brazil.
Helen Quézia da Silva AguiarCurso de Medicina Veterinária, Universidade Federal do Tocantins, BR-153, km 112, Araguaína, TO, 77804-970, Brazil.
Clarissa Amorim Silva de CordovaCurso de Medicina, Universidade Federal do Tocantins, Av. Dionísio Farias, 838, Araguaína, TO, 77814-350, Brazil.
Alberto Yim JúniorCurso de Medicina Veterinária, Universidade Federal do Tocantins, BR-153, km 112, Araguaína, TO, 77804-970, Brazil.
Fabiano Mendes de CordovaPrograma de Pós-Graduação em Sanidade Animal e Saúde Pública nos Trópicos, Universidade Federal do Tocantins, BR-153, km 112, Araguaína, TO, 77804-970, Brazil. fabiano.patologia@uft.edu.br.ORCID http://orcid.org/0000-0003-4735-4108
Universidade Federal do Tocantins · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR) 470252/2013-8
6 · The paper itself

Abstract

Thiamine deficiency (TD) produces severe neurodegenerative lesions. Studies have suggested that primary neurodegenerative events are associated with both oxidative stress and inflammation. Very little is known about the downstream effects on intracellular signaling pathways involved in neuronal death. The primary aim of this work was to evaluate the modulation of p38

Indexed as

AnimalsBehavior, AnimalBody WeightBrainCell SurvivalChromansDimethyl SulfoxideEatingHeme Oxygenase-1InflammationMaleMembrane ProteinsMiceNeuroprotective AgentsOxidative Stressp38 Mitogen-Activated Protein Kinases6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acidChromansDimethyl SulfoxideHeme Oxygenase-1Hmox1 protein, mouseMembrane ProteinsNeuroprotective Agentsp38 Mitogen-Activated Protein KinasesPyrithiamineDimethyl sulfoxideInflammationNeurodegenerationOxidative stressTrolox

Identifiers

PMID31989470
OpenAlexW3003743719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.