Evidence map›Paper›PMID 31989445›Full record

ArticleJournal of neurovirology2020

Medication management abilities are reduced in older persons living with HIV compared with healthy older HIV- controls.

Sarah A Cooley, Robert H Paul, Beau M Ances

Open access · greenAbstract readComparative Study
In one paragraph

Article in Journal of neurovirology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. The Effects of Prescribed Medications on Depressive Symptoms and Neurocognitive Performance in People With HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  2. Review
  3. Verbal Learning Mediates the Relationship Between Executive Functions and a Laboratory Task of Medication Management in HIV Disease.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2021
    Article
  4. Article
  5. Beliefs and attitudes about deprescription in older HIV-infected patients: ICARD Project.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2021
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sarah A CooleyDepartment of Neurology, Washington University School of Medicine in Saint Louis, 660 S Euclid Ave, Campus Box 8111, St. Louis, MO, 63110, USA.
Robert H PaulDepartment of Psychological Sciences, University of Missouri-Saint Louis, St. Louis, MO, USA.
Beau M AncesDepartment of Neurology, Washington University School of Medicine in Saint Louis, 660 S Euclid Ave, Campus Box 8111, St. Louis, MO, 63110, USA. bances@wustl.edu.
Washington University in St. Louis · USMissouri Institute of Mental Health · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Functional Imaging Reserve in NeuroHIV (FIRN)R01MH118031 · NIMH · WASHINGTON UNIVERSITY · PI ANCES, BEAU M · 2018 to 2023
$3.7M
Exercise Training to Improve Brain Health in Older HIV+ IndividualsR01NR015738 · NINR · WASHINGTON UNIVERSITY · PI ANCES, BEAU M · 2015 to 2019
$3.0M
Frailty and Brain Integrity in Older HIV-infected IndividualsR01NR014449 · NINR · WASHINGTON UNIVERSITY · PI ANCES, BEAU M · 2013 to 2017
$2.4M
NEUROIMAGING AND NEUROBEHAVIORAL BASIS OF RISKY DECISION-MAKING IN ADOLESCENTSR01NR012907 · NINR · WASHINGTON UNIVERSITY · PI ANCES, BEAU M · 2011 to 2015
$1.9M
THE EFFECTS OF AGE AND HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON BRAIN FUNCTIONR01NR012657 · NINR · WASHINGTON UNIVERSITY · PI ANCES, BEAU M · 2010 to 2014
$1.9M
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NIMH NIH HHS R01 MH118031NINR NIH HHS R01 NR012657NINR NIH HHS R01 NR012907NINR NIH HHS R01 NR014449NINR NIH HHS R01 NR015738
6 · The paper itself

Abstract

Although combination antiretroviral therapy (cART) has simplified over the past decade, polypharmacy is increasing for older people living with HIV (PLWH) due to the emergence of multiple health comorbidities. This study examined predictors of, and relationships between, objective (Medication Management Test-Revised (MMT-R)) and self-reported medication management ability in older (≥ 50 years) PLWH (n = 146) compared with HIV-uninfected (HIV-) individuals (n = 60). PLWH scored worse on the MMT-R and had a higher pill burden compared with HIV- individuals. MMT-R failure was predicted by HIV status, race, reading level, and worse executive functioning, as well as history of Hepatitis C and detectable viral load in PLWH. Self-reported ability to manage medications did not relate to MMT-R score. Older PLWH may not self-describe concerns regarding their ability to manage complex medication regimens. Our results emphasize the need for objective measurements of medication management ability.

Indexed as

Medication AdherenceSelf AdministrationAgedAnti-HIV AgentsFemaleHIV InfectionsHumansMaleMiddle AgedPolypharmacyAnti-HIV AgentsExecutive functionHIVMedication therapy managementNeuropsychologyPolypharmacy

Identifiers

PMID31989445
PMCPMC7261252
OpenAlexW3003586161

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.