Evidence map›Paper›PMID 31989393›Full record

ArticleMycopathologia2020

Primary Central Nervous System Infection by Histoplasma in an Immunocompetent Adult.

Sérgio M de Almeida, Elaine C M Imano, Vania A Vicente, Renata R Gomes, Ana P Trentin, Kassiely Zamarchi, Gabriela X Schneider, Rosangela L Pinheiro, Nickolas M da Silva, G S de Hoog

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Mycopathologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Towards Genomic Criteria for Delineating Fungal Species.Journal of fungi (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Sérgio M de AlmeidaDiagnostic Support Unit, Hospital of Clinics, Federal University of Parana, Curitiba, Parana, Brazil.
Elaine C M ImanoMicrobiology, Parasitology and Pathology Postgraduate Program, Pathology Basic Department, Federal University of Parana, Curitiba, Parana, Brazil.
Vania A VicenteMicrobiology, Parasitology and Pathology Postgraduate Program, Pathology Basic Department, Federal University of Parana, Curitiba, Parana, Brazil. vaniava63@gmail.com.ORCID http://orcid.org/0000-0002-2953-4861
Renata R GomesMicrobiology, Parasitology and Pathology Postgraduate Program, Pathology Basic Department, Federal University of Parana, Curitiba, Parana, Brazil.
Ana P TrentinDiagnostic Support Unit, Hospital of Clinics, Federal University of Parana, Curitiba, Parana, Brazil.
Kassiely ZamarchiMicrobiology, Parasitology and Pathology Postgraduate Program, Pathology Basic Department, Federal University of Parana, Curitiba, Parana, Brazil.
Gabriela X SchneiderMicrobiology, Parasitology and Pathology Postgraduate Program, Pathology Basic Department, Federal University of Parana, Curitiba, Parana, Brazil.
Rosangela L PinheiroDepartment of Mycology, Hospital of Clinics, Federal University of Parana, Curitiba, Parana, Brazil.
Nickolas M da SilvaBioprocess Engineering and Biotechnology Department, Federal University of Parana, Curitiba, Parana, Brazil.
G S de HoogWesterdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
Universidade Federal do Paraná · BRHospital de Clínicas Universidade Federal do Paraná · BRRadboud University Nijmegen · NL

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 312811/2018-7
6 · The paper itself

Abstract

Central nervous system (CNS) infection by Histoplasma capsulatum is a rare disease in immunocompromised individuals in endemic areas. About one quarter of cases result from hematogenous dissemination. A 23-year-old upholsterer with chronic occipital headache had developed intracranial hypertension and dizziness, incoordination with ataxic gait, and acute confusion 5 months prior to admission. Laboratory examinations and chest roentgenogram were normal. Postcontrast T1-weighted MRI of the brain revealed a multiple ring-enhancing cerebellar, brain stem and parietal lobe lesions, and meningeal contrast enhancement. Cerebrospinal fluid culture was positive for H. capsulatum species complex, which was confirmed by phylogenetic analysis. Thirteen years after the diagnosis and treatment, there was no H. capsulatum recurrence; sequels related to complications due to the ventriculoperitoneal shunt. This case shows a primary neurological presentation of cerebral histoplasmosis, without meningitis or disseminated disease in nonimmune-compromised patient. The authors propose a categorization of the diagnosis of CNS histoplasmosis. Routine diagnostics of sibling species within the H. capsulatum complex proved to be difficult.

Indexed as

HistoplasmaAdultCentral Nervous System InfectionsCerebrospinal FluidDNA, Ribosomal SpacerGenes, FungalHistoplasmosisHumansMalePhylogenyYoung AdultDNA, Ribosomal SpacerCentral nervous systemEncephalitisHistoplasma capsulatum complexHistoplasma suramericanumHistoplasmosis

Identifiers

PMID31989393
OpenAlexW3001220360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.