ArticleMetabolomics : Official journal of the Metabolomic Society2020
Rumen fluid metabolomics of beef steers differing in feed efficiency.
Article in Metabolomics : Official journal of the Metabolomic Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 52 citations in OpenAlex.
- Temporal dynamics of ruminal metabolome and fermentation in response to molasses-treated Guinea grass-cowpea silage.Veterinary and animal science · 2026Article
- Comparative Study on Growth Performance and Rumen Digestive Metabolism Between Cull Beef Cows and Fattening Bulls.Animals : an open access journal from MDPI · 2026Article
- Rumen Microbiota, Predicted Metabolic Pathways, and Fermentation Parameters Exhibit Production-System-Specific Associations in Cattle and Goats.Microorganisms · 2026Article
- Mechanisms Underlying the Impact of Feed-to-Gain Ratio Differences on Nutrient Metabolism in Simmental and Simmental × Hereford Crossbred Cattle Fed a Low-Energy Diet.Animals : an open access journal from MDPI · 2026Article
- Investigating the potential role of propionylcarnitine in milk pentadecanoic acid synthesis in Chinese holstein dairy cows using multi-omics analysis.BMC genomics · 2026Article
- Metabolic and metataxonomic changes in lactating holstein dairy cows during the transition from heat stress to the recovery period.Journal of animal science and technology · 2026Article
- Mechanisms and Applications of Gastrointestinal Microbiota-Metabolite Interactions in Ruminants: A Review.Microorganisms · 2025Review
- Integrative Multi-Omics Analysis of the Rumen inMicroorganisms · 2025Article
- Microbial Biomarkers Differ for Various Feed Efficiency Metrics in Beef Cattle.Animals : an open access journal from MDPI · 2025Article
- Metabolomic Profiling of Serum Reveals Energy Metabolism Differences in Nellore Bulls with Divergent Growth Rates during Feedlot Finishing.ACS omega · 2025Article
- Metabolomic analysis of rumen fluid in Tan sheep reveals sex-specific key metabolites and pathways associated with residual feed intake.Scientific reports · 2025Article
- Performance improvements and increased ruminal microbial interactions in Angus heifers via supplementation with native rumen bacteria during high-grain challenge.Scientific reports · 2025Article
- Review
- Ruminal and feces metabolites associated with feed efficiency, water intake and methane emission in Nelore bulls.Scientific reports · 2023Article
- Effect of Rumen-Protected Methionine on Metabolic Profile of Liver, Muscle and Blood Serum Samples of Growing German Simmental Bulls Fed Protein-Reduced Diets.Metabolites · 2023Article
- Exploring the rumen microbiota of Hu lambs in response to diet with paper mulberry.Applied microbiology and biotechnology · 2023Article
- Rumen Microbiota Predicts Feed Efficiency of Primiparous Nordic Red Dairy Cows.Microorganisms · 2023Article
- Fermented Total Mixed Ration Alters Rumen Fermentation Parameters and Microbiota in Dairy Cows.Animals : an open access journal from MDPI · 2023Article
- Effect of supplementation with ruminal probiotics on growth performance, carcass characteristics, plasma metabolites, methane emissions, and the associated rumen microbiome changes in beef cattle.Journal of animal science · 2023Article
- Plasma Metabolomic Profiling Reveals Preliminary Biomarkers of Pork Quality Based on pH Value.Foods (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBeef is the most consumed red meat in the United States, and the US is the largest producer and consumer of beef cattle globally. Feed is one of the largest input costs for the beef cattle industry, accounting for 40-60% of the total input costs. Identifying methods for improving feed efficiency in beef cattle herds could result in decreased cost to both producers and consumers, as well as increased animal protein available for global consumption.
methodsIn this study, rumen fluid was collected from low- (n = 14) and high-RFI (n = 15) steers. Rumen fluid was filtered through a 0.22 µM syringe filter, extracted using 0.1% formic acid in acetonitrile:water:methanol (2:2:1) and injected into the Dionex UltiMate 3000 UHPLC system with an Exactive Plus Orbitrap MS. Peaks were identified using MAVEN and analyzed using MetaboAnalyst 4.0 and SAS. Significance was determined using an α ≤ 0.05.
resultsEight metabolites were greater in low-RFI steers compared to high-RFI steers, including 3,4-dihydroxyphenylacetate, 4-pyridoxate, citraconate, hypoxanthine, succinate/methylmalonate, thymine, uracil, and xylose (P ≤ 0.05). These metabolites were predominantly involved in amino acid and lipid metabolism.
conclusionsRumen fluid metabolomes differ in steers of varying feed efficiencies. These metabolites may be used as biomarkers of feed efficiency, and may provide insight as to factors contributing to differences in feed efficiency that may be exploited to improve feed efficiency in beef cattle herds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.