Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2020
Distribution of peripheral lesions identified by mydriatic ultra-wide field fundus imaging in diabetic retinopathy.
Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 33 citations in OpenAlex.
- Ultra-widefield color fundus photography in diabetic retinopathy: from panretinal assessment to multimodal integration.Frontiers in medicine · 2026Review
- Association of predominant peripheral lesions with retinal microvasculature and risk of vitreous hemorrhage in proliferative diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Intergrader Agreement on Qualitative and Quantitative Assessment of Diabetic Retinopathy Severity Using Ultra-Widefield Imaging: INSPIRED Study Report 1.Diagnostics (Basel, Switzerland) · 2025Article
- Examining the Visual Search Behaviour of Experts When Screening for the Presence of Diabetic Retinopathy in Fundus Images.Journal of clinical medicine · 2025Article
- Relationship between macular perfusion and lesion distribution in diabetic retinopathy.Eye (London, England) · 2024Observational
- Programmatically Localizing Diabetic Retinopathy Features in 45-Degree Retinal Photographs Using Anatomical Colocation.Journal of clinical medicine · 2024Article
- Retinal vascular morphological characteristics in diabetic retinopathy: an artificial intelligence study using a transfer learning system to analyze ultra-wide field images.International journal of ophthalmology · 2024Article
- Comparison of diabetic retinopathy severity grading on ETDRS 7-field versus ultrawide-field assessment.Eye (London, England) · 2023Article
- Inter-observer agreement in grading severity of diabetic retinopathy in wide-field fundus photographs.Eye (London, England) · 2023Article
- Widefield and Ultra-Widefield Retinal Imaging: A Geometrical Analysis.Life (Basel, Switzerland) · 2023Article
- Digital innovations for retinal care in diabetic retinopathy.Acta diabetologica · 2022Review
- Predominant peripheral lesions in patients with diabetic retinopathy and its association with systemic comorbidities.Indian journal of ophthalmology · 2022Observational
- Progress of Imaging in Diabetic Retinopathy-From the Past to the Present.Diagnostics (Basel, Switzerland) · 2022Review
- Prediction of Refractive Error Based on Ultrawide Field Images With Deep Learning Models in Myopia Patients.Frontiers in medicine · 2022Article
- Macular Edema and Visual Acuity Observation after Cataract Surgery in Patients with Diabetic Retinopathy.Journal of healthcare engineering · 2022Article
- Quantitative Imaging Biomarkers in Age-Related Macular Degeneration and Diabetic Eye Disease: A Step Closer to Precision Medicine.Journal of personalized medicine · 2021Review
- Telemedicine in diabetic retinopathy screening in India.Indian journal of ophthalmology · 2021Review
- Barriers in establishing systematic diabetic retinopathy screening through telemedicine in low- and middle-income countries.Indian journal of ophthalmology · 2021Review
- Comparison of Two Ultra-Widefield Cameras With High Image Resolution and Wider View for Identifying Diabetic Retinopathy Lesions.Translational vision science & technology · 2021Article
- The Role of Ultra-Widefield Fundus Imaging and Fluorescein Angiography in Diagnosis and Treatment of Diabetic Retinopathy.Current diabetes reports · 2021Review
Corrections and comments
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Authors and funding
11 authors at 9 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyze the distribution of diabetic retinopathy (DR) lesions in an Indian population using ultra-wide field (UWF) fundus imaging.
methodsSeven hundred fifteen subjects (1406 eyes) with diabetic retinopathy in India were enrolled in this multicenter, prospective, observational study using UWF pseudocolor imaging with Optos Daytona Plus (Optos plc, Dunfermline, Scotland, UK). Images were transmitted to Doheny Image Reading Center, Los Angeles, CA, for grading. The ETDRS grid was overlaid on stereographic projections of UWF images, and images were graded independently by 2 masked graders. Lesion distribution was graded as predominantly central (PCL) or predominantly peripheral (PPL) according to previous criteria, considering both lesion number and area. An image was graded as PPL if > 50% of the lesion area was seen in at least one peripheral field as compared with the corresponding ETDRS field. Diabetic retinopathy severity was also assessed based on the International Classification of Diabetic Retinopathy (ICDR) grading scale. The main outcome measures were lesion distribution (PPL versus PCL): overall and within specific fields in eyes with various grades of DR.
resultsLesion distribution was rated to be PPL in 37% of eyes and PCL in 63% of eyes (P < 0.003). The frequency of a PPL distribution varied significantly across all ICDR severity levels, with frequencies of mild non-proliferative DR (NPDR) (30.9%), moderate NPDR (40.3%), severe NPDR (38.5%) and PDR (34.9%), P = 0.005. When assessing which individual fields were rated to show a PPL distribution, the frequency was greatest in field 4 and least in field 7. For any grade of DR, temporal fields showed the greatest PPL frequency, followed in order by the superior, inferior, and nasal fields (P < 0.001). Only 3.5% of eyes showed PPL distribution in all five peripheral fields.
conclusionsOne-third of the UWF images showed a PPL distribution in this cohort with the temporal quadrant having the widest distribution of PPL. As the PPL distribution varied significantly between various grades of DR, UWF imaging may prove to be important for screening of referral warranted retinopathy.
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