Evidence map›Paper›PMID 31989268›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2020

G protein coupled oestrogen receptor 1, aromatase, 17β-HSD and cAMP level in mutational falsetto.

Saime Sagiroglu, Metin Kılınc, Adem Doganer, Nagihan Bilal, Israfil Orhan, Mehmet Akif Kılıc

Abstract read
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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Saime SagirogluDepartment of Otorhinolaringology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Avsar Campus, 46100, Kahramanmaras, Turkey. ssguzelsoy@hotmail.com.ORCID http://orcid.org/0000-0003-2608-7274
Metin KılıncDepartment of Medical Biochemistry, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Adem DoganerDepartment of Biostatistics and Medical Informatics, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaras, Turkey.
Nagihan BilalDepartment of Otorhinolaringology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Avsar Campus, 46100, Kahramanmaras, Turkey.
Israfil OrhanDepartment of Otorhinolaringology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Avsar Campus, 46100, Kahramanmaras, Turkey.
Mehmet Akif KılıcDepartment of Otorhinolaringology, Faculty of Medicine, Medeniyet University, Istanbul, Turkey.
Kahramanmaraş Sütçü İmam University · TRIstanbul Medeniyet University · TR

Funding

Kahramanmaraş Sütçü Imam Üniversitesi 2018/2-47 M
6 · The paper itself

Abstract

objectivesPuberphonia or mutational falsetto (MF) is seen more in males, and hormonal changes are considered to be among the aetiological causes. Therefore, the aim of this study was to investigate the molecules [G protein-coupled oestrogen receptor 1 (GPER-1), aromatase, 17-beta-hydroxysteroid dehydrogenase (17β-HSD), cyclic adenosine monophosphate (cAMP) levels] related to receptors and pathways in patients with MF.

methodsThe study included 30 MF patients and a control group of 30 healthy individuals. Voice recordings were made of the MF patients and acoustic analyses were applied. The serum GPER-1, aromatase, 17β-HSD, cAMP levels and TSH, estradiol, prolactin, progesterone, and testosterone levels were evaluated in venous blood samples.

resultsIn the MF patients, the GPER-1 level determined of mean 3.68 (1.95-4.26) pg/ml, 17 beta dehydrogenase of 5.25 (2.73-6.77) ng/ml, and cAMP of 24.62 (11.62-30.35) ng/ml were statistically signficantly higher than those of the control group (p = 0.008, p = 0.002, p = 0.003, respectively). The aromatase level in the MF patients was found to be 3.48 (2.01-4.91) and the difference between the two groups was not statistically significant (p = 0.067).

conclusionThe GPER-1, 17β-HSD, and cAMP levels were found to be higher in the MF patients than in the control group, suggesting that they could be of importance in the diagnosis and treatment of MF.

Indexed as

AromataseCyclic AMPEstrogen Receptor alphaEstradiolEstradiol DehydrogenasesEstrogensGTP-Binding ProteinsHumansMaleMutationReceptors, EstrogenReceptors, G-Protein-CoupledVoice DisordersAromataseCyclic AMPEstradiolEstradiol DehydrogenasesEstrogen Receptor alphaEstrogensGPER1 protein, humanGTP-Binding ProteinsHSD17B1 protein, humanReceptors, EstrogenReceptors, G-Protein-Coupled17 beta hydroxysteroid dehydrogenase (17β-HSD)AromataseGPER-1 (G protein-coupled estrogen receptor)Gyclic adenosine monophosphate (cAMP)Mutational falsettoVoice analysis

Identifiers

PMID31989268
OpenAlexW3003457951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.